多聚免疫球蛋白受体(pIgR/SC)在肺癌组织的表达及其临床意义

doi:10.3969/j.issn.1004-616x.2008.03.004

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (3): 182-184.doi: 10.3969/j.issn.1004-616x.2008.03.004

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Expression of Polymeric Immunoglobulin Receptor (pIgR/SC) in Lung Cancer Tissues

XIAO Ting1, LIN Dong-mei2, LI Min1, ZHANG Ying1, YI Sheng-zhong1, CHENG Shu-jun1, GAO Yan-ning1,

1. Department of Etiology and Carcinogenesis, Cancer Institute (Hospital), Peking Union Medical College ＆ Chinese Academy of Medical Sciences, Beijing 100021; 2. Department of Pathology, Cancer Institute (Hospital), Peking Union Medical College ＆ Chinese Academy of Medical Sciences, Beijing 100021,China

Received:2007-12-27 Revised:2008-03-05 Online:2008-05-30 Published:2008-05-30
Contact: GAO Yan-ning

Abstract

Abstract: BACKGROUND AND AIM: To explore the expression levels of pIgR/SC in lung cancer tissues and its clinical significance. MATERIALS AND METHODS: Tissue microarray (TMA) containing 484 sample of lung cancer, including 344 with squamous cell carcinoma (SCC), 93 with adenocarcinoma (ADC), 47 with small cell lung cancer (SCLC), and 30 normal controls from the same patients, were evaluated by immunohistochemistry (IHC). RESULTS: Immunohistochemical study showed that pIgR positive staining was found in 54.1％ lung cancers (especially in non-small cell lung cancer), significantly higher than in normal lung tissues(6.7％). The pIgR/SC expression was found in 66.3％ of SCC, 34.4％ and 4.3％ of ADC and SCLC specimens respectively (P<0.001). But pIgR/SC protein levels were not related to tumor differentiation and stage. CONCLUSION: Expression of pIgR/SC may reflect the histological difference of lung cancer, and over expression of pIgR/SC may happen at the early stage of non-small cell lung cancer.

Key words: pIgR/SC, lung cancer, tissue microarray, immunohistochemistry

XIAO Ting, LIN Dong-mei, LI Min, ZHANG Ying, YI Sheng-zhong, CHENG Shu-jun, GAO Yan-ning, . Expression of Polymeric Immunoglobulin Receptor (pIgR/SC) in Lung Cancer Tissues[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(3): 182-184.

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Expression of Polymeric Immunoglobulin Receptor (pIgR/SC) in Lung Cancer Tissues

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