EphB2在结肠癌组织中的表达及其与血管生成的关系

doi:10.3969/j.issn.1004-616x.2008.04.015

Abstract

Abstract: BACKGROUND AND AIM: To detect the expression of receptor tyrosine kinase EphB2 as well as its relationship with angiogenesis in colon carcinoma，and explore the possible mechanism. MATERIALS AND METHODS: The expressions of EphB2 in 10 normal tissues and 43 colon carcinoma were detected by immunohistochemisty, and stromal microvessel density (MVD) was counted according to the results of CD34 detectedby immunohistochemisty. RESULTS:The majority of colon carcinomas expressed EphB2 in the cytoplasm. There was positive correlation between EphB2 expression in the cytoplasm and tumor differentiation，but negative correlation between EphB2 and tumor infiltration depth. Expression of EphB2 was positive correlation with MVD in immunoreation. CONCLUSION: EphB2 may play suppressive role in carcinogenesis and progression of colon carcinoma.EphB2 may achieve its tumor suppressor through regulation of tumor angiogenesis.

Key words: colon carcinoma, receptor tyrosine kinase B2, anti_oncogene, immunohistochemistry

WANG Yong_zhan, GAO Qing. Expression of EphB2 in Colon Carcinoma and Its Relationship with Angiogenesis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(4): 308-311.

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Expression of EphB2 in Colon Carcinoma and Its Relationship with Angiogenesis

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