Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (4): 322-324.doi: 10.3969/j.issn.1004-616x.2008.04.019

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Effect of β_carotene on Genetic Damage Induced by Mitomycin_C in Bone Marrow Cells of Mice

ZHANG Xin_wang，YANG Jian_yi，LI Li，DU Sheng_jia   

  1. Shanxi Medical University, Taiyuan 030001, China
  • Received:2007-06-26 Revised:2007-10-30 Online:2008-07-30 Published:2008-07-30

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Abstract: BACKGROUND AND AIM: To assess the protective effects of β_carotene(βC) on DNA damage induced by mitomycin_C (MMC) in bone marrow cells of mice. MATERIALS AND METHODS: Two batches of mice were primed orally with βC in concentrations of 3 and 30 mg/kg for 8 days and then followed by MMC intraperitoneal injection at dose of 2 mg/kg on day 9. DNA and chromosome damage were examined by single cell gel electrophoresis(SCGE) and chromosome aberrations analysis. RESULTS: The comet frequency, tail length and the chromosomal aberration rate of two doses of βC were significantly lower than those of the MMC group. CONCLUSION: To some extent,βC could protect the bone marrow cells of mice from damage induced by MMC in vivo.

Key words: β_carotene, mitomycin_C, SCGE, chromosomal aberrations, DNA damage