香加皮水提物抑制诱导红白血病细胞K562分化的初步研究

doi:10.3969/j.issn.1004-616x.2008.06.008

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (6): 449-450.doi: 10.3969/j.issn.1004-616x.2008.06.008

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The Study of Cortex Periplocae Extract on the Differentiation of K562 Cells

LI Jun-xin1, SHAN Bao-en2

1. Women and Children's Medical Center, Qingdao 266000，Shandong； 2. Science and Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China

Received:2007-11-21 Revised:2008-06-05 Online:2008-11-30 Published:2008-11-30

Abstract

Abstract: BACKGROUND AND AIM: To investigate the effect of cortex periplocae extract (CPE) on the differentiation of tumor cells K562 in vitro. MATERIALS AND METHODS: We examined the morphological changes of K562 cells after cultured with CPE; and investigated the induction effect of CPE on the production of Hb from K562 cells by using colorimetry. RESULTS: K562 cells morphology were destroyed by CPE. CPE also markedly reduced the production of Hb from K562 cells. CONCLUSION: CPE could kill K562 cells to some extent, but could not induce the differentiation of K562 cells.

Key words: cortex periplocae, K562, kill, differentiation

LI Jun-xin, SHAN Bao-en. The Study of Cortex Periplocae Extract on the Differentiation of K562 Cells[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(6): 449-450.

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The Study of Cortex Periplocae Extract on the Differentiation of K562 Cells

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