Carcinogenesis, Teratogenesis & Mutagenesis ›› 2010, Vol. 22 ›› Issue (2): 134-137.doi: 10.3969/j.issn.1004-616x.2010.02.014

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Expression of p73 in reactive hyperplastic lymphadenitis and follicular lymphomas

YANG Kai-yan1;JIN Zhen-lin2;YU Kang2;WANG Su-fen1   

  1. 1. The Pathology Department of Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000; 2. The Hematology Department of Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000, Zhejiang, China
  • Received:2009-09-14 Revised:2009-11-27 Online:2010-03-30 Published:2010-03-30
  • Contact: YANG Kai-yan

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Abstract: OBJECTIVE: To detect the expression of P73 protein and p73 mRNA in reactive hyperplasitic lymphadenitis(RHL) and follicular lymphomas(FL). To explore the relationship between p73 gene and its methylation status. To explore and discuss the possible roles of p73 gene in the development and progression of RHL and FL. METHODS: P73 protein expression was detected in 20 cases of RHL and 18 cases of FL by immunohistochemistry. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to observe p73 mRNA expression. We also used the methylation-specific polymerase chain reaction(MSP) to detect the methylation state of p73 gene CD,FL and RHL. RESULTS: P73 protein expression was positive in 12 of 18 FL and 16 of 20 in RHL by immunohistochemistry. The expression rates of p73 mRNA were the same in FL and RHL(P>0.05). Methylation of p73 gene was found in 2 cases of 18 FL(11.1％), while p73 mRNA and protein expression were not found in these. No methylation of p73 gene was found in FL. CONCLUSION: There was no statistically significant differences of p73 expression between RHL and FL. Methylation of p73 was uncommon in FL and RHL.

Key words: reactive hyperplasitic lymphadenitis, follicular lymphoma, p73, methylation

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