微小染色体维持蛋白4在胃癌中的表达及与幽门螺杆菌感染的关系

doi:10.3969/j.issn.1004-616x.2010.04.007

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2010, Vol. 22 ›› Issue (4): 279-282.doi: 10.3969/j.issn.1004-616x.2010.04.007

Previous Articles Next Articles

The expression of minichromo- some maintenance proteins 4 in gastric cancer and correlation with H.pylori infection

RONG Fang1;WANG Yong2;WANG Man-gui2;HOU Heng1;LI Li-fen1

1. Department of Medicine, Medical College, Datong University in Shanxi, Datong 037008; 2.Department of Pathology,The Fifth People's Hospital of Datong, Datong 037006, Shanxi, China

Received:2010-01-15 Revised:2010-03-26 Online:2010-07-30 Published:2010-07-30
Contact: RONG Fang

Abstract

Abstract: OBJECTIVE: To investigate the expression of minichromosome maintenance proteins 4 (MCMp4) in gastric cancer and precancerous condition and its correlation with helicobacter pylori (Hp) infection. METHODS: The expression of MCMp4 and the infection of Helicobacter pylori were studied by immunohistochemical methods in 140 gastric specimens including 25 chronic superficial gastritis(CSG), 30 gastric ulcer (GU), 35 chronic atrophic gastritis (CAG) and 50 gastric cancers (GC). RESULTS: In CSG,GU,CAG and GC, the expressions of MCMp4 and Hp were increased. The expression of MCMp4 in Hp positive group was significantly higher than that in negative group. The expression of MCMp4 was positively correlated with infection of Hp(r=0.457, P<0.05). CONCLUSION: MCMp4 and Hp may play important roles in carcinogenesis and progression of gastric cancer. The evaluation of MCMp4 and Hp could provide theoretical basis for diagnosing, evaluating prognosis and guiding treatment of gastric cancer.

Key words: minichromosome maintenance proteins 4, helicobacter pylori, immunohistochemistry

CLC Number:

R735.2

RONG Fang, WANG Yong, WANG Man-gui, HOU Heng, LI Li-fen. The expression of minichromo- some maintenance proteins 4 in gastric cancer and correlation with H.pylori infection[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2010, 22(4): 279-282.

[1]	JIAO Wenjing, ZHANG Jinyan, MA Ming, GUO Xiujuan, FENG Junhua, SHAO Junguo, JIAO Wenpeng. Expression and clinical significance of MTDH and FoxM1 in hepatocellular carcinomas [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 349-353,359.
[2]	ZHANG Shimin, ZHAO Ruijun. Expression of protein tyrosine phosphatase receptor J in breast cancer tissues and its relationship with clinical prognosis [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(4): 276-279,285.
[3]	YANG Xiuyuan, PAN Yuelong. Expression of CD10 protein in colorectal carcinomas and its clinical significance [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 344-349.
[4]	HUANG Zhuangcheng, WANG Honghao, SHEN Peilin, LIN Ming'en, HE Xuejun. Expression and clinical significance of Notch signalingrelated proteins in cystitis glandularis and bladder cancer [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(5): 374-377,383.
[5]	YANG Xingxiao, ZOU Naiyi, LI Qiaofang, ZHANG Xueyuan, SONG Heng, LIU Zhikun, MA Ming, SHAN Baoen, ZHU Shuchai. Significance in expression of RNF2 and PCNA proteins in esophageal squamous cancer cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(4): 254-257.
[6]	LI Yang, XING Long, MOHAMMED H, MA Xiaolong, XIE Fuqiang, FENG Zhenghu, CHE Yinfu. Clinicopathological significance of expression of thioredoxin and its reductase-1 in tongue squamous cell carcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 87-91.
[7]	WANG Yuan, DENG Xiaofei. Effect of DNA glycosylase OGG1 against Helicobacter pylori-induced DNA damage in gastric epithelial cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 92-97,102.
[8]	MA Kun, WU Haoyu, LI Peng, WANG Li, LI Baixiang. Induction of dopaminergic neuron degeneration by atrazine in substantia nigra in adolescent rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(4): 251-255.
[9]	LIU Dezhong, CHANG Bo, LIN Feixiang, LI Xuedong. β-catenin expression in hepatocellular carcinoma and its effect on prognosis [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(4): 300-303.
[10]	FENG Shuitu, CHEN Yide, CHEN Yuqiang, LIN Yubiao, ZHENG Wenhui. Differential expression of Gadd45α in Helicobacter Pylori-infected human gastric cancer and clinical significance [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(5): 353-358,392.
[11]	ZHAI Xiaoran, JIANG Mei, ZHAO Xiaoting, GU Meng, YUE Wentao. Clinical significance of PFTK1 expression in human non-small cell lung cancer [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(3): 231-235.
[12]	CHEN Guangcan, HONG Liangli, HUANG Jiexiong, XIE Aosi, GUO Dan, LIU Shuhui. Expression of GST-π and P-gp in gastric cardia cancer and their clinical significance in the Chaoshan high risk area [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(1): 36-40.
[13]	QIN Jiesheng, HONG Liangli, LIN Xuni, WANG Huige, QIU Qiancheng. Expression and significance of Sema4C in laryngeal squamous carcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(3): 230-233.
[14]	FANG Shaobin, DENG Xiaoling, CHEN Jun, CHEN Yonghui, XU Mingyan. The expression and clinical relevance of integrin αvβ6 and JunB in oral squamous cell carcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(3): 234-238,241.
[15]	LAN Yu, LIU Dongdong, LIN Ming'en, HONG Yingkai, HUANG Jiansheng, CHEN Si, HE Xuejun. Expression and clinical significance of silent information regulator 1 in bladder urothelial cell carcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(2): 125-128.

The expression of minichromo- some maintenance proteins 4 in gastric cancer and correlation with H.pylori infection

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments