Abstract:

OBJECTIVE: To investigate the toxicity of medical propellant HFC-134a，in order to provide scientific basis for promoting the application of HFC-134a on medicine. METHODS：60 Kunming mice were divided into 5 groups，12 mice each group，male and female in half：0，100，500，1 000，5 000 mg/m3. The acute toxicity was conducted with mice exposed for 4 hours，to observe the change of animal behavior. Then all mice were sacrificed after 7 days. The change of mice weight and the pathomorphology of liver，kidney and pancreas were observed. RESULTS：Compared with negative control group，the weight of liver，kidney and pancreas did not show any abnormality. No animal died under the maximum dose. The average weight increase was (26.3±5.8) g，and there was no irritation or toxicity found through respiratory tract contamination． CONCLUSION：There were no obvious acute toxicity and side effects on the experimental subjects. HFC-134a could be used as a medicine safely.

Key words: HFC-134a, propellant, LC50, acute toxicity