[1] Capell BC,Berger SL. Genome-wide epigenetics[J]. J Invest Dermatol,2013,133(6):e9.[2] Shikun He,Xiaohua Li,Nymph Chan,et al. Epigenetic mechanisms in ocular disease[J]. Molecular Vision,2013, 19(5):665-674.[3] Feil R,Fraga MF. Epigenetics and the environment:emerging patterns and implications[J]. Nat Rev Genet,2011,13(2): 97-109.[4] Umer M,Herceg Z. Deciphering the epigenetic code:an overview of DNA methylation analysis methods[J]. Antioxid Redox Signal,2013,18(15):1972-1986.[5] Shakya K,O'Connell MJ,Ruskin HJ. The landscape for epigenetic/epigenomic biomedical resources[J]. Epigenetics, 2012,7(9):982-986.[6] Yang X,Lay F,Han H,et al. Targeting DNA methylation for epigenetic therapy[J]. Trends Pharmacol Sci,2010,31(11): 536-546.[7] Karimi M,Johansson S,Ekstrom TJ. Using LUMA:a Luminometric-based assay for global DNA-methylation[J]. Epigenetics, 2006,1(1):45-48.[8] Xu X,Gammon MD,Hernandez-Vargas H,et al. DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study[J]. FASEB J,2012,26(6):2657-2666.[9] Yang AS,Estecio MR,Doshi K,et al. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements[J]. Nucleic Acids Res,2004,32(3): e38.[10] Khulan B,Thompson RF,Ye K,et al. Comparative isoschizomer profiling of cytosine methylation:the HELP assay[J]. Genome Res,2006,16(8):1046-1055.[11] Weber M,Davies JJ,Wittig D,et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells[J]. Nat Genet,2005,37(8):853-862.[12] Ruike Y,Imanaka Y,Sato F,et al. Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing[J]. BMC Genomic,2010,11:137.[13] Down TA,Rakyan VK,Turner DJ,et al. A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis[J]. Nat Biotechnol,2008,26(7):779-785.[14] Shen HR,Qiu LH,Zhang ZQ,et al. Genome-Wide Methylated DNA Immunoprecipitation analysis of patients with polycystic ovary syndrome[J]. PLoS One,2013,8(5): e64801.[15] Berdasco M,Fraga MF,Esteller M. Quantification of global DNA methylation by capillary electrophoresis and mass spectrometry[J]. Methods Mol Biol,2009,507:23-34.[16] Yoshida T,Yamashita S,Takamura-Enya T,et al. Alu and Satalpha hypomethylation in Helicobacter pylori-infected gastric mucosae[J]. Int J Cancer,2011,128(1):33-39.[17] Herman JG,Graff JR,Myohanen S,et al. Methylation-specific PCR:a novel PCR assay for methylation status of CpG islands[J]. Proc Natl Acad Sci USA,1996,93(18):9821-9826.[18] 朱 燕. DNA甲基化的分析与状态检测[J]. 现代预防医学,2005,32(9):1070-1073.[19] Li Q,Ahuja N,Burger PC,et al. Methylation and silencing of the Thrombospondin-1 promoter in human cancer[J]. Oncogene, 1999,18(21):3284-3289.[20] 黄朝晖,吴玉玉. 甲基化敏感限制酶结合定量PCR检测DNA甲基化方法的建立与应用[J]. 中华病理学杂志,2011,40(4):263-265.[21] Xiong Z,Laird PW. COBRA:a sensitive and quantitative DNA methylation assay[J]. Nucleic Acids Res,1997,25(12): 2532-2534.[22] Akey DT,Akey JM,Zhang K,et al. Assaying DNA methylation based on high-throughput melting curve approaches [J]. Genomics,2002,80(4):376-384.[23] Yan PS,Chen CM,Shi H,et al. Dissecting complex epigenetic alterations in breast cancer using CpG island microarrays[J]. Cancer Res,2001,61(23):8375-8380.[24] Frommer M,McDonald LE,Millar DS,et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands[J]. Proc Natl Acad Sci USA,1992,89(5):1827-1831.[25] Taylor KH,Kramer RS,Davis JW,et al. Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing[J]. Cancer Res,2007, 67(18):8511-8518.[26] Grigg G,Clark S. Sequencing 5-methylcytosine residues in genomic DNA[J]. Bioessays,1994,16(6):431-436.[27] Ronaghi M. Pyrosequencing sheds light on DNA sequencing[J]. Genome Res,2001,11(1):3-11.[28] 虞闰六,张 锋. 高通量检测全基因组DNA甲基化方法的建立[J]. 中华肿瘤防治杂志,2011,18(21):1672-1675.[29] Uhlmann K,Brinckmann A,Toliat MR,et al. Evaluation of a potential epigenetic biomarker by quantitative methyl-single nucleotide polymorphism analysis[J]. Electrophoresis,2002, 23(24):4072-4079.[30] 张晓丹,武海萍. 焦测序技术及其在遗传分析中的应用[J]. 分析化学评述与进展,2006,34(4):582-586.[31] 卉 叶,刘云龙,邹秉杰,等. 焦磷酸测序中PCR引物与测序引物的设计[J]. 分析化学研究报告,2013,15(5):744-748.[32] Lister R,Ecker JR. Finding the fifth base:genome-wide sequencing of cytosine methylation[J]. Genome Res,2009, 19(6):959-966.[33] Irizarry RA,Ladd-Acosta C,Carvalho B,et al. Comprehensive high-throughput arrays for relative methylation (CHARM) [J]. Genome Res,2008,18(5):780-790.[34] Laird PW. Principles and challenges of genomewide DNA methylation analysis[J]. Nat Rev Genet,2010,11(3):191-203. |