含生物碱类成分中、成药不良反应的文献调查与分析

doi:10.3969/j.issn.1004-616x.2014.06.011

Abstract

Abstract:

OBJECTIVE: After exploring the clinical features and resuscitation methods of adverse drug reaction (ADR) caused by medicines containing Alkaloid components，the authors analyzed the reasons of this kind of ADR. METHODS：The authors set up the ADR-database through collecting and collating the documents containing the key words “Alkaloids” and “ADR” from CNKI database，NCBI database as well as related books，then analyzed the data using SPSS 17.0. RESULTS：Aconitine in Chinese medicines is most likely to cause adverse durg reaction. Alkloid drugs are often used in therapy of pains and infection，where they could also cause rapidly-developing ADR at the same time，with a high incidence in middle-aged and the elderly. Over dosage and erroneous ingestion happened most frequently among the various reasons leading to ADR and neurological damage accounted for a high percentage of the ADR during clinical therapy. CONCLUSION：The author made suggestions on the adminstration of Chinese medicines containing alkaloids：Firstly，we should pay attention to the clinical dosage，followed by close monitoring the patients. Last but not least，we should deal with the suspected-ADR timely.

Key words: adverse , drug , reaction, alkaloids, database, literature , search

QIN Dan，WEI Jin-feng，WANG Ai-ping，JIN Hong-tao. Literature search and analysis of adverse drug reaction of Chinese medicines containing alkaloid components[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2014.06.011.

References

[1] 张国睿. 正视中药不良反应及完善相关监测体系的探讨[D]. 黑龙江：黑龙江中医药大学，2010：4- 45.

[2] 张双春，李世忠，高晓村，等. 乌头类药物中毒2604例文献综述[J]. 北京中医杂志，1993，(3)：56.

[3] 况时祥. 马钱子不良反应4例[J]. 江西中医药，2008，39 (305)：45.

[4] 李克荣，刘明乐. 大剂量山豆根致恶心呕吐2例[J]. 医药导报，2011，3(30)：386.

[5] 徐国银. 曼陀罗中毒原因分析[J]. 安徽中医临床杂志，1994， 11(2)：138.

[6] 李光凤. 曼陀罗中毒误诊1例[J]. 滨州医学院学报，2002， 25(1)：76.

[7] 郝向春. 口服雷公藤多试片出现多形性红斑型药疹l例[J]. 中国中药杂志，1993，18(3)：182.

[8] 马慧珍. 罂粟蒴果煎剂中毒1例[J]. 宁夏医药通讯，1982， (26)：57.

[9] 肖赛玉. 雪上一枝蒿中毒2例报告[J]. 新中医，2002，12 (34)：45.

[10] 杨星辉. 服附子理中丸致面部浮肿2例[J]. 中国执业药师，1999， (4)：39.

[11] 关继华. 服雷公藤片过量死亡一例[J]. 新疆中医药，1992， (4)：21.

[12] 朱亚峰. 中药中成药解毒手册[M]. 北京：人民军医出版社， 2009， 4：1-519.

[13] 黄婧文. 中药乌头不良反应原因分析和对策[J]. 中国药业， 2011， 20(22)：55-57.

[14] 曹维珍. 口服"骨刺消痛液"中毒1例[J]. 陕西中医，1994， 15(6)：282.

[15] 杨立平. 中药不良反应报告分析[J]. 中国全科医学，2009， 14(70)：2459-2470.

[16] 李娆娆，张志杰，王祝举，等. 近60年中国毒副作用及不良反应文献分析[J]. 中国实验方剂学杂志，2010，16(15)： 213- 221.

[17] 曹国建，阮学东. 雷公藤多甙片致结节性红斑1例[J]. 中国中药杂志，1994，(19)：759.

[18] 王庆伦. 就曼陀罗果实中毒琐谈[J]. 江西中医药，1985， (2)：54

[19] 黄光照，李玲，刘良，等. 雷公藤中毒的尸检病理变化——附4例尸检报告[C]. 第五届全国雷公藤学术会议文汇编，2008：165-168.

[20] 孙鲁英，王耀献，周静成. 雷公藤多甙致重度贫血一例[J]. 临床内科杂志，2005，2(22)：84.

[21] 胡成文. 雷公藤急性中毒致死一例[J]. 安徽医药，1995， 16(6)：10.

[22] 梁志奇，毛璐. 中药汤剂不良反应分析及其评价[J]. 中国实验方剂学杂志，2010，16(9)：230- 232.

[23] 姚向阳，陶维能. 误服曼陀罗子中毒病例分析[J]. 湖北中医杂志，2009，31(5)：55.

[24] 陈文贵. 对含生物碱中药炮制的探讨[J]. 新疆中医药，1989，(1)：49-51.

[25] Vanherweghem JL，Depierreux M，Tielemans C，et al. Rapidly progressive interstitial renal fibrosis in young women：association with slimming regimen including Chinese herbs[J]. Lancet，1993，341( 8842)：387-391.

[26] 贾春伶. 雷公藤不良反应的文献调查与分析[J]. 北京中医，2006，1(25)：45.

[27] 鲍志东，叶晨，黄欣. 马兜铃属植物的肾毒性[J]. 国外医学中医中药分册，2001，23(5)：259-269.

[28] Lord GM，Tagore R，Cook T，et al. Nephropathy caused by Chinese herbs in the UK[J]. Lancet，1999，354(9177)：481-482.

[29] Nortier JL，Martinez MC，Schmeiser HH. Urothelial carcinoma associatde with the use of a Chinese herb (Aristolochia fangchi) [J]. N Engl J Med，2000，342(23)：1686-1692.

[30] 代闻蒂，郭静波. 中药不良反应产生的原因及预防[J]. 中国民族民间医药，2011，8(15)：31-32.

Literature search and analysis of adverse drug reaction of Chinese medicines containing alkaloid components

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	WANG Yaokun, CHEN Juexiao, ZHANG Mingyuan, SHAO Changli, YANG Yu, SHANG Yu. Database analysis of genome variations and targeted drug screening of anaplastic thyroid cancers [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 53-57.
[2]	DU Qiang, YAO Yiyong, ZENG Gang. Expression and clinical significance of ASPM in lung adenocarcinoma according to the TCGA database [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 457-463.
[3]	TAO Yan, LI Lanlan, LU Jianzhong, LIU Shanhui, FU Shengjun, ZHANG Jing. Expression and clinical significance of FOXO3 gene in bladder cancer based on bioinformatics database [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 374-379.
[4]	GAO Jie, ZHANG Xiao, WEI Chao. Involvement of differentially expressed miRNA in prognosis of pancreatic cancers [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(3): 173-179.
[5]	DU Juan, HU Xiangyang, LIU Dan, HU Wei, CHEN Tao. Inhibitory effect of total alkaloids of Tougucao on bone metastasis of breast cancer cells in mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(6): 435-441.
[6]	LIU Ying, WANG Ke, HE Yangting, XIAO Jinrong, WANG Huanzhuo, LI Yangkai, WEI Sheng. Prognosis-associated lncRNA signature in lung squamous cell carcinomas based on TCGA database [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(6): 468-472,478.
[7]	ZHANG Dan-yan1，ZHANG Dan-mei，MA Ming-fu，LU Jing，LI Xin-sheng，YANG Yu-you，LI Lian-bing. The predictive analysis of Down's syndrome using the D21S11 locus in IdentifilerTM system [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2013, 25(5): 389-.
[8]	GAO Zhi-di，SHAO Wei，LI Li，MA Xiao-ye， SUN Yu-ping. The correlation between HPV infection subtype and lung squamous cell carcinoma in Qingdao region [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2013, 25(2): 111-114.
[9]	LI Lei，DENG Yan-chao，ZHAO Yan，CHEN Yan. Methylation of the FHIT gene in esophageal carcinoma in Kazakh and Han and relationship with prognosis [J]. , 2012, 24(2): 132-135.
[10]	YU Lan1, WANG Wan-ying2, GAN Huai-yong1. Correlation of Staphylococcus Aureus L-form Infection and Mutation of k-ras in Ovarian Carcinomas [J]. , 2009, 21(2): 98-101.
[11]	OU Yu-rong;ZHANG Hong-fu;LIU De-chun. Clinical Significance of P53 gene in Serum and Stool of Patients with Colorectal Cancer [J]. , 2005, 17(6): 370-373.
[12]	WANG Xiao-yan;CHAN Ying;LIANG Zi-qing;CAO Neng;HUANG Yun-cao XIA ; Xiao-ling;WANG Xu. A Study on the NAT1 Genetic Polymorphism in the Lung Cancer Cases of Yunnan Population [J]. , 2005, 17(3): 148-151.
[13]	GUO Li; MA Ye-gang;SUN Zhong-fu; et al. Detection of DNA Repair Gene: ERCC2/XPD exon 6 Mutation from Human by Nested Polymerase Chain Reaction (NPCR) [J]. , 2005, 17(1): 33-35.
[14]	WU Jian-zhong, SHEN Zong-li, CHEN Sen-qing, XUE Kai-xian. STUDY ON C - ERBB - 2 GENE AMPLIFICATION IN FROZEN SECTIONS OF BREAST CANCER [J]. , 2000, 12(1): 47-048.
[15]	Zhou Hailan , Yu Kang , Chen Yi. EXPRESSION OF WILMS’TUMOR GENE( WT1) IN LEUKEMIA AND ITS CLINICAL IMPLICATION [J]. , 1999, 11(5): 222-224.