Carcinogenesis, Teratogenesis & Mutagenesis ›› 2016, Vol. 28 ›› Issue (4): 314-316,331.doi: 10.3969/j.issn.1004-616x.2016.04.014

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Determination of residual organic solvents in allogeneic bones

FU Bufang1, WANG Li2   

  1. 1. National Institutes for Food and Drug Control, Beijing 100050;
    2. Hebei Province Testing Institute for Medical Devices and Pharmaceutical Packing, Shijiazhuang 050061, Hebei, China
  • Received:2016-01-08 Revised:2016-06-28 Online:2016-07-31 Published:2016-07-31

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Abstract: OBJECTIVE: To establish a GC-MS method for determination of residual organic solvents in allogeneic bones. METHODS: A SCAN mode of GC-MS was used to determine the presence of residual organic solvents in allogeneic bones and a SIM mode was used to quantify ten kinds of organic solvent residues. RESULTS: Several organic solvents were observed, including methanol, ethanol and dichloromethane, etc. Residual benzene was found in many samples. The total residual organic solvents in allogeneic bones were up to 167.45 μg/g. The linear R of the quantitative method was above 0.99. The average recovery rate was between 90.5%-113.8% and the precision was between 1.00%-3.19%. CONCLUSION: Our data show that the established GC-MS method was accurate and suitable for the determination of residual organic solvents in allogeneic bones.

Key words: gas chromatography-mass spectrometry, allogeneic bone, organic solvent, residual

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