Carcinogenesis, Teratogenesis & Mutagenesis ›› 2023, Vol. 35 ›› Issue (1): 26-29.doi: 10.3969/j.issn.1004-616x.2023.01.005

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Factors that influence live-birth rates after artificial insemination with husbands' sperm

ZHANG Qingjian, SONG Ge, ZHU Xiaoli, ZHAN Zehu, CAI Xiaolin, LI Yan   

  1. Key Laboratory of Male Reproduction and Genetics of National Health Commission, Reproductive Center of Guangdong Provincial Reproductive Science Institute, Guangzhou 510600, Guangdong, China
  • Received:2022-09-27 Revised:2022-12-05 Published:2023-02-09

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Abstract: OBJECTIVE: To understand influencing factors on live-birth rates after artificial insemination with husbands-- sperm (AIH). METHODS: The study included 2391 AIH cycles from January 2011 to September 2021 in a reproductive center of the Guangdong Provincial Reproductive Science Institute. The Chi-square and the generalized estimation equation (GEE) were used to analyze factors affecting the live-birth rates. RESULTS: Inseminated women who were ≥40 years old had significantly reduced live birth rates than the younger ones ([OR=0.270，95%CI(0.0840，0.874)]). On day 3 after insemination，menstrual luteinizing hormone (LH) >8.00 IU/L，the ovulation cycle，3 eggs ovulated per cycle and prewash total motile sperm >2×107 significantly increased live birth rates of insemination women [OR=1.734，95%CI(1.167，2.576)；OR=1.472，95%CI(1.037，2.090)；OR=1.567，95%CI(1.007，2.437)；and OR=2.232，95%CI(1.295，3.847)，respectively. CONCLUSION: Our data indicate that age of females，day 3 menstrual LH levels，treatment protocols，ovulation numbers per cycle and prewash total motile sperm numbers significantly affected live-birth rates after AIH.

Key words: AIH, live birth rates, luteinizing hormone, generalized estimation equation

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