Carcinogenesis, Teratogenesis & Mutagenesis ›› 2023, Vol. 35 ›› Issue (3): 215-218.doi: 10.3969/j.issn.1004-616x.2023.03.010

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Differential analysis of chromosomal aberrations among radiation workers in medical institutions

ZHANG Zhongxin1, ZHANG Ruifeng1, LIU Xiaoming1, MENG Qianqian1, DANG Xuhong1, ZHANG Jingyun2, ZHAI Hongyan3   

  1. 1. China Institute for Radiation Protection, Taiyuan 030006, Shanxi;
    2. MacroStat Clinical Research Co., Ltd., Guangzhou 510080, Guangdong;
    3. Linfen People's Hospital, Linfen 041081, Shanxi, China
  • Received:2022-11-20 Revised:2023-05-12 Published:2023-06-03

Abstract: OBJECTIVE:To understand the impact of job type,gender,and employment duration on exposure doses of radiation workers in medical institutions,and to compare efficiency of chromosomal aberration analysis and thermoluminescence monitoring in assessing occupational health of the workers. METHODS:By using logistic regression analysis,the chromosomal aberration rates from different groups of radiation workers were analyzed based on three variables:job type,gender,and employment duration. The ROC curve was constructed based on individual dose monitoring results. RESULTS:Chromosome aberration rates of nuclear medicine workers were significantly higher than those who carried out X-ray imaging diagnosis (P<0.05),while the rates for radiation therapy and interventional radiology workers were not statistically significant (P>0.05). There was no significant (P>0.05) impact from gender and employment duration on the chromosome aberration rates. The consistency between the chromosome aberration analysis and the abnormal rates of thermoluminescence monitoring (assuming that it exceeded 1 mSv as abnormal) was good. CONCLUSION:The radiation exposure doses of staff in the nuclear medicine department were significantly higher than that of staff in radiation diagnosis,radiotherapy and intervention. The evaluation criteria for the two means of occupational health monitoring (personal dose monitoring and chromosome aberration analysis) of radiation workers were inconsistent.

Key words: chromosome aberration analysis, personal dose monitoring, ROC analysis, radiation workers

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