苯并[b]荧蒽和二苯并[a,h]蒽对成年雄性大鼠氧化应激和炎症因子的影响

doi:10.3969/j.issn.1004-616x.2024.01.003

Abstract

Abstract: OBJECTIVE: To investigate effects of benzo[b]fluoranthene (BbFA) and dibenzo[a, h]anthracene(Dah A) exposure on oxidative stress and inflammatory factors in rats.METHODS: After 1 week of acclimatization, 48 adult male SD rats were randomly divided into exposed and control groups.The rats were exposed to Bb FA and Dah A by intratracheal instillation twice a week in 4 weeks.Inflammatory factors in BALF and serum, and oxidative stress factors in lung tissue and serum were determined.RESULTS: Serum activity of SOD was significantly decreased in the Dah A-exposed groups (P<0.05).Meanwhile, the Bb FA+Dah A exposed groups showed significantly increased levels of MDA, NO, i-NOS in the lung tissue compared with the control group (P<0.05), and the levels of MDA and i-NOS in the Bb FA+Dah A combined exposure group were significantly higher than that of the Bb FA-exposed and the Dah A-exposed groups (P<0.05).Additionaly, the content of MDA in the Bb FA+Dah A combined exposure group was significantly higher than low dose group of Bb FA-exposed group and Dah A-exposed group (P<0.05).The levels of IL-6 in the Bb FA+Dah A combined exposure group were significantly up-regulated compared with the Bb FA-exposed and the Dah A-exposed groups(P<0.05).CONCLUSION: Our results demonstrated that Bb FA and Dah A caused changes in inflammatory and oxidative factors that were related to inhibition of SOD activity and elevation of i NOS activity, and MDA, NO and IL-6 levels.

Key words: BbFA, DahA, oxidant stress, inflammatory factors

CLC Number:

R994.6

KANG Zhen, YU Tianyi, LIU Xiaobo, HONG Qianqi, CAI Shurui, YAN Hai. Effects of benzo[b]fluoranthene and dibenzo[a, h]anthracene on oxidative stress and flammatory factors in rats[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2024, 36(1): 16-20.

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Effects of benzo[b]fluoranthene and dibenzo[a, h]anthracene on oxidative stress and flammatory factors in rats

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