基于网络药理学探讨葛根治疗肝损伤的作用机制

doi:10.3969/j.issn.1004-616x.2024.02.006

Abstract

Abstract: OBJECTIVE：To investigate the active ingredients，targets， action pathways and mechanisms of actions of Pueraria lobata for treating liver injury. METHODS：According to the public databases such as TCMID， TCMIP， TCMSP， GeneCards， and basic network pharmacological methods such as KEGG pathway analysis， potential pathways of pueraria for treating liver injury were predicted. RESULTS： The main active components of puerariae showed intersection with liver injury. Functional analysis， enrichment analysis and molecular docking showed that formononetin，β-sitosterol and ESR1，coumestrol，3′-methoxydaidzein and PPARG have good affinity for docking. The interaction between formononetin and ESR1 was the strongest (-8.04 kcal/ mol). It was concluded that the mechanism of Pueraria lobata treating liver injury was related to ESR1 and PPARg-mediated pathway. CONCLUSION：The use of Pueraria lobata for treatment of liver injury may be mainly due to regulating the growth，differentiation and physiological functions of hepatocytes through estrogen receptor signaling pathway and PPAR-γ activation and regulation of target gene transcription expression pathway，and alleviating the mechanism of oxidative stress induced liver injury and hepatocyte apoptosis.

Key words: network pharmacology, Pueraria lobata, liver injury, active ingredient, mechanism

CLC Number:

R966

LIU Shibu, ZHENG Jifan, ZHANG Li, MA Libo, DUO Hui, LIU Mengqi. Network pharmacology-based prediction of Pueraria lobata for treating liver injury[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2024, 36(2): 118-123.

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Network pharmacology-based prediction of Pueraria lobata for treating liver injury

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