[1] 程书钧. 衰老和恶性肿瘤──防治的思考[J]. 癌变·畸变·突变, 2021, 33(3): 161-162. [2] HASTON S, GONZALEZ-GUALDA E, MORSLI S, et al. Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer[J]. Cancer Cell, 2023, 41(7): 1242-1260. [3] GU M, LIU Y, ZHENG W H, et al. Combined targeting of senescent cells and senescent macrophages: a new idea for integrated treatment of lung cancer[J]. Semin Cancer Biol, 2024, 106/107: 43-57. [4] WANG H, FU H P, ZHU R G, et al. BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake[J]. Aging (Albany NY), 2020, 12(10): 9240-9259. [5] PRASANNA P G, CITRIN D E, HILDESHEIM J, et al. Therapy-induced senescence: opportunities to improve anticancer therapy[J]. J Natl Cancer Inst, 2021, 113(10): 1285-1298. [6] CHENG W K, FU Y, LIN Z X, et al. Lipoteichoic acid restrains macrophage senescence via β-catenin/FOXO1/REDD1 pathway in age-related osteoporosis[J]. Aging Cell, 2024, 23(3): e14072. [7] ABE J I, IMANISHI M, LI S Y, et al. An ERK5-NRF2 axis mediates senescence-associated stemness and atherosclerosis[J]. Circ Res, 2023, 133(1): 25-44. [8] WANG L L, HONG W X, ZHU H, et al. Macrophage senescence in health and diseases[J]. Acta Pharm Sin B, 2024, 14(4): 1508-1524. [9] DE MAEYER R P H, CHAMBERS E S. The impact of ageing on monocytes and macrophages[J]. Immunol Lett, 2021, 230: 1-10. [10] WADA H, OTSUKA R, GERMERAAD W T V, et al. Tumor cell-induced macrophage senescence plays a pivotal role in tumor initiation followed by stable growth in immunocompetent condition[J]. J Immunother Cancer, 2023, 11(11): e006677. [11] KONG S J, LI J X, PAN X, et al. Allicin regulates Sestrin2 ubiquitination to affect macrophage autophagy and senescence, thus inhibiting the growth of hepatoma cells[J]. Tissue Cell, 2024, 88: 102398. [12] ZHANG X Q, ZHUANG M Y, ZHANG H F, et al. Melatonin-mediated cGAS-STING signal in senescent macrophages promote TNBC chemotherapy resistance and drive the SASP[J]. J Biol Chem, 2025, 301(5): 108438. [13] LALIBERTé C, BOSSé B, BOURDEAU V, et al. Senescent macrophages release inflammatory cytokines and RNA-loaded extracellular vesicles to circumvent fibroblast senescence[J]. Biomedicines, 2024, 12(5): 1089. [14] DENG Y, CHEN Q Y, YANG X, et al. Tumor cell senescence-induced macrophage CD73 expression is a critical metabolic immune checkpoint in the aging tumor microenvironment[J]. Theranostics, 2024, 14(3): 1224-1240. [15] HICKSON L J, LANGHI PRATA L G P, BOBART S A, et al. Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease[J]. EBioMedicine, 2019, 47: 446-456. [16] THADATHIL N, SELVARANI R, MOHAMMED S, et al. Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma[J]. Aging Cell, 2022, 21(8): e13676. [17] CUI C Y, DRISCOLL R K, PIAO Y L, et al. Skewed macrophage polarization in aging skeletal muscle[J]. Aging Cell, 2019, 18(6): e13032. [18] MINHAS P S, LIU L, MOON P K, et al. Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation[J]. Nat Immunol, 2019, 20(1): 50-63. |