基于中医时间医学探讨衰老微环境参与肿瘤的机制

doi:10.3969/j.issn.1004-616x.2025.04.010

Abstract

CLC Number:

R273

LIU Han, XU Jie, LIU Guangyi, et al.. Exploring the mechanism of aging microenvironment involved in tumors based on chronomedicine of traditional Chinese medicine[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2025, 37(4): 296-299.

References

[1] LóPEZ-OTíN C, BLASCO M A, PARTRIDGE L, et al. The hallmarks of aging[J]. Cell, 2013, 153(6): 1194-1217.
[2] BRAY F, LAVERSANNE M, SUNG H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263.
[3] JU W, ZHENG R S, ZHANG S W, et al. Cancer statistics in Chinese older people, 2022: current burden, time trends, and comparisons with the US, Japan, and the republic of Korea[J]. Sci China Life Sci, 2023, 66(5): 1079-1091.
[4] FANE M, WEERARATNA A T. How the ageing microenvironment influences tumour progression[J]. Nat Rev Cancer, 2020, 20(2): 89-106.
[5] 中医出版中心. 黄帝内经素问[M]. 北京: 人民卫生出版社, 2012.
[6] 中医出版中心. 灵枢经[M]. 北京: 人民卫生出版社, 2012: 140-142.
[7] 周珍, 王兴华. 浅谈对中医时间医学的认识[J]. 四川中医, 2015, 33(2): 36-38.
[8] 黄宗勗. 生物钟与时间医学[J]. 四川生理科学杂志, 1989, 11(3): 25.
[9] 王立早. 子午流注传真[M]. 南昌: 江西科学技术出版社, 1989: 5-8.
[10] 潘迪, 李佶, 何云云. 基于“天人相应” 理论的中医时间学研究进展[J]. 中医学报, 2020, 35(12): 2584-2588.
[11] 陈雄. 不同时间点电针对肝癌小鼠昼夜节律时相作用及其Per基因影响研究[D]. 成都: 成都中医药大学, 2017.
[12] 刘臻, 赵娜, 谢晨, 等. 电针对失眠大鼠睡眠-觉醒昼夜节律及褪黑素节律的影响[J]. 中华中医药杂志, 2016, 31(9): 3695-3699.
[13] 徐飞鸿, 毕海连, 伍会健. 昼夜节律与细胞周期[J]. 中国生物化学与分子生物学报, 2013, 29(11): 1010-1016.
[14] 陈曦, 敬然, 李雨, 等. 基于卫阳循行探讨生物钟基因对变应性鼻炎昼夜节律的影响[J]. 世界科学技术-中医药现代化, 2025, 27(2): 431-436.
[15] MANDER B A, WINER J R, WALKER M P. Sleep and human aging[J]. Neuron, 2017, 94(1): 19-36.
[16] SHIMBA S, ISHII N, OHTA Y, et al. Brain and muscle Arnt-like protein-1(BMAL1), a component of the molecular clock, regulates adipogenesis[J]. Proc Natl Acad Sci U S A, 2005, 102(34): 12071-12076.
[17] WELZ P S, BENITAH S A. Molecular connections between circadian clocks and aging[J]. J Mol Biol, 2020, 432(12): 3661-3679.
[18] QU M, ZHANG G X, QU H, et al. Circadian regulator BMAL1: clock promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle[J]. Proc Natl Acad Sci USA, 2023, 120(2): e2214829120.
[19] TAMPAKAKIS E, GANGRADE H, GLAVARIS S, et al. Heart neurons use clock genes to control myocyte proliferation[J]. Sci Adv, 2021, 7(49): eabh4181.
[20] GUBINA-VAKULIK G I, BONDARENKO L A, SOTNIK N N. Long round-the-clock illumination as a factor of accelerated ageing of pineal gland[J]. Adv Gerontol, 2007, 20(1): 92-95.
[21] WU Y H, SWAAB D F. The human pineal gland and melatonin in aging and Alzheimer’s disease[J]. J Pineal Res, 2005, 38(3): 145-152.
[22] CAVADINI G, PETRZILKA S, KOHLER P, et al. TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription[J]. Proc Natl Acad Sci USA, 2007, 104(31): 12843-12848.
[23] 程钰, 于中阳, 胡凯文. 衰老微环境与肿瘤[J]. 癌症进展, 2020, 18(12): 1189-1193.
[24] ZHOU Z J, WEI J H, JIANG W B. Characterization of aging tumor microenvironment with drawing implications in predicting the prognosis and immunotherapy response in low-grade gliomas[J]. Sci Rep, 2022, 12(1): 5457.
[25] COPPé J P, PATIL C K, RODIER F, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor[J]. PLoS Biol, 2008, 6(12): 2853-2868.
[26] OVADYA Y, KRIZHANOVSKY V. Senescent cells: SASPected drivers of age-related pathologies[J]. Biogerontology, 2014, 15(6): 627-642.
[27] CUOLLO L, ANTONANGELI F, SANTONI A, et al. The senescence-associated secretory phenotype (SASP) in the challenging future of cancer therapy and age-related diseases[J]. Biology (Basel), 2020, 9(12): 485.
[28] 郑文鸽, 秦雪梅, 高丽, 等. 衰老相关分泌表型的作用机制及相关药物研究进展[J]. 药学学报, 2020, 55(1): 8-14.
[29] LORETI M, SACCO A. The jam session between muscle stem cells and the extracellular matrix in the tissue microenvironment[J]. NPJ Regen Med, 2022, 7(1): 16.
[30] ITOH G, TAKAGANE K, FUKUSHI Y, et al. Cancer-associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T-cell suppression[J]. Mol Oncol, 2022, 16(1): 166-187.
[31] BARTLING B, DESOLE M, ROHRBACH S, et al. Age-associated changes of extracellular matrix collagen impair lung cancer cell migration[J]. FASEB J, 2009, 23(5): 1510-1520.
[32] SHI X Q, LI J, QIAN L, et al. Correlation between elastic parameters and collagen fibre features in breast lesions[J]. Clin Radiol, 2018, 73(6): 595.e1-595.e7.
[33] 努尔斯曼古丽·买买提明, 张莉. 衰老微环境对肿瘤发生发展的影响及其机制[J]. 中国肿瘤生物治疗杂志, 2022, 29(8): 756-761.
[34] LACONI E, CHERI S, FANTI M, et al. Aging and cancer: the waning of community bonds[J]. Cells, 2021, 10(9): 2269.
[35] SONG S L, TCHKONIA T, JIANG J, et al. Targeting senescent cells for a healthier aging: challenges and opportunities[J]. Adv Sci (Weinh), 2020, 7(23): 2002611.
[36] RUHLAND M K, ALSPACH E. Senescence and immunoregulation in the tumor microenvironment[J]. Front Cell Dev Biol, 2021, 9: 754069.
[37] LIAN J Y, YUE Y, YU W N, et al. Immunosenescence: a key player in cancer development[J]. J Hematol Oncol, 2020, 13(1): 151.
[38] DEMARIA M, O’LEARY M N, CHANG J H, et al. Cellular senescence promotes adverse effects of chemotherapy and cancer relapse[J]. Cancer Discov, 2017, 7(2): 165-176.

Exploring the mechanism of aging microenvironment involved in tumors based on chronomedicine of traditional Chinese medicine

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