衰老肿瘤相关成纤维细胞及其在肿瘤进展中的作用

doi:10.3969/j.issn.1004-616x.2025.04.013

Abstract

CLC Number:

R730.2

FENG Yingying, XIAO Ting, FENG Lin. Senescent tumor-associated fibroblasts and their role in tumor progression[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2025, 37(4): 308-309,335.

[1] SCHMITT C A, WANG B S, DEMARIA M. Senescence and cancer - role and therapeutic opportunities[J]. Nat Rev Clin Oncol, 2022, 19(10): 619-636.
[2] CHEN Y, MCANDREWS K M, KALLURI R. Clinical and therapeutic relevance of cancer-associated fibroblasts[J]. Nat Rev Clin Oncol, 2021, 18(12): 792-804.
[3] HIGASHIGUCHI M, MURAKAMI H, AKITA H, et al. The impact of cellular senescence and senescence-associated secretory phenotype in cancer-associated fibroblasts on the malignancy of pancreatic cancer[J]. Oncol Rep, 2023, 49(5): 98.
[4] WANG T, NOTTA F, NAVAB R, et al. Senescent carcinoma-associated fibroblasts upregulate IL8 to enhance prometastatic phenotypes[J]. Mol Cancer Res, 2017, 15(1): 3-14.
[5] FAN G J, YU B, TANG L, et al. [TSPAN8+] myofibroblastic cancer-associated fibroblasts promote chemoresistance in patients with breast cancer[J]. Sci Transl Med, 2024, 16(741): eadj5705.
[6] SAHAI E, ASTSATUROV I, CUKIERMAN E, et al. A framework for advancing our understanding of cancer-associated fibroblasts[J]. Nat Rev Cancer, 2020, 20(3): 174-186.
[7] KURASHIGE M, KOHARA M, OHSHIMA K, et al. Origin of cancer-associated fibroblasts and tumor-associated macrophages in humans after sex-mismatched bone marrow transplantation[J]. Commun Biol, 2018, 1: 131.
[8] BELLE J I, SEN D, BAER J M, et al. Senescence defines a distinct subset of myofibroblasts that orchestrates immunosuppression in pancreatic cancer[J]. Cancer Discov, 2024, 14(7): 1324-1355.
[9] YE J Y, BAER J M, FAGET D V, et al. Senescent CAFs mediate immunosuppression and drive breast cancer progression[J]. Cancer Discov, 2024, 14(7): 1302-1323.
[10] CAMPISI J, D’ADDA DI FAGAGNA F. Cellular senescence: when bad things happen to good cells[J]. Nat Rev Mol Cell Biol, 2007, 8(9): 729-740.
[11] CHILDS B G, DURIK M, BAKER D J, et al. Cellular senescence in aging and age-related disease: from mechanisms to therapy[J]. Nat Med, 2015, 21(12): 1424-1435.
[12] GABASA M, RADISKY E S, IKEMORI R, et al. MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence[J]. Cancer Lett, 2021, 507: 1-12.
[13] YANG G, ROSEN D G, ZHANG Z H, et al. The chemokine growth-regulated oncogene 1(Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis[J]. Proc Natl Acad Sci USA, 2006, 103(44): 16472-16477.
[14] HASSONA Y, CIRILLO N, LIM K P, et al. Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-β[J]. Carcinogenesis, 2013, 34(6): 1286-1295.
[15] ORJALO A V, BHAUMIK D, GENGLER B K, et al. Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network[J]. Proc Natl Acad Sci USA, 2009, 106(40): 17031-17036.
[16] NELSON G, WORDSWORTH J, WANG C F, et al. A senescent cell bystander effect: senescence-induced senescence[J]. Aging Cell, 2012, 11(2): 345-349.
[17] LEE J J, PARK I H, RHEE W J, et al. HMGB1 modulates the balance between senescence and apoptosis in response to genotoxic stress[J]. FASEB J, 2019, 33(10): 10942-10953.
[18] MENG J S, LI Y, WAN C, et al. Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis[J]. JCI Insight, 2021, 6(23): e146334.
[19] PAPADOPOULOU A, KLETSAS D. Human lung fibroblasts prematurely senescent after exposure to ionizing radiation enhance the growth of malignant lung epithelial cells in vitro and in vivo[J]. Int J Oncol, 2011, 39(4): 989-999.
[20] KRTOLICA A, PARRINELLO S, LOCKETT S, et al. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging[J]. Proc Natl Acad Sci USA, 2001, 98(21): 12072-12077.
[21] COPPé J P, PATIL C K, RODIER F, et al. A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen[J]. PLoS One, 2010, 5(2): e9188.
[22] GUO Y N, AYERS J L, CARTER K T, et al. Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15[J]. Aging Cell, 2019, 18(6): e13013.
[23] ZABRANSKY D J, CHHABRA Y, FANE M E, et al. Fibroblasts in the aged pancreas drive pancreatic cancer progression[J]. Cancer Res, 2024, 84(8): 1221-1236.
[24] PARRINELLO S, COPPE J P, KRTOLICA A, et al. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation[J]. J Cell Sci, 2005, 118(Pt 3): 485-496.
[25] RUHLAND M K, LOZA A J, CAPIETTO A H, et al. Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis[J]. Nat Commun, 2016, 7: 11762.
[26] ASSOULINE B, KAHN R, HODALI L, et al. Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8⁺ T cell activation and limit responsiveness to immunotherapy in mice[J]. Nat Commun, 2024, 15(1): 6162.

Senescent tumor-associated fibroblasts and their role in tumor progression

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LI Zixuan, HUANG Ji, SUN Zhenxiao. Construction of a cisplatin-induced polyploid giant cancer cell model [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2024, 36(6): 483-490.
[2]	CUI Xufang, WANG Quankai, JIN Huiping, LI Xinwei, GU Yiting, WUHAN Baolier, KANG Tongying, XU Jianning. Glycidyl methacrylate affects malignant transformation of 16HBE cells through the ERK/MMP14 signaling pathway [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2024, 36(4): 261-267.
[3]	ZHU Wenbiao, YAN Chunmei, QIU Bo, XIE Shoucheng, XIAO Huanqin, LIU Gaomin. Expression of secreted frizzled-related protein 4 in hepatocellular carcinoma, and relationship with clinicopathological index and prognosis [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2024, 36(4): 288-293,297.
[4]	. [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2024, 36(4): 325-327,333.
[5]	ZHANG Kaitai. Aging and malignant tumors—the neglected immunosenescence [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2024, 36(3): 169-171.
[6]	FU Yongqing, XU Sanhui, ZHAO Yan, WANG Lili. Relationships between SPP1, DEC1, C1QTNF6 and clinicopathologic outcomes of oral squamous cell carcinomas [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2024, 36(2): 107-111,117.
[7]	LIU Ruixue, LI Desheng, ZHANG Liwei. Characteristics of serum lipidomics among Kazakhs with esophageal squamous cell carcinomas based on the UPLC-MS/MS method [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2024, 36(1): 21-28,34.
[8]	WANG Quankai, JIN Huiping, LI Xinwei, CUI Xufang, GU Yiting, WUHAN Baolier, KANG Tongying, XU Jianning. ALDH3A1 activates GMA-induced malignant transformation of epithelial mesenchymal transition in 16HBE cells via the IL-6/STAT3 signalling pathway [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(6): 405-411.
[9]	ZHU Wenbiao, QIU bo, XIE Shoucheng, XIAO Huanqin, LIU Gaomin. Expression and clinical significance of transmembrane protein 79 in hepatocellular carcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(6): 426-430.
[10]	XU Jinhua, LI Jingjing, WU Guofeng, REN Yajun, WANG Xue, ZHANG Qianyun. Correlation and prognostic value of serum miR-146a with TNF-α and Treg in patients with non-small cell lung cancer [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(6): 462-466.
[11]	YANG Shangying, HUANG Mingxiang, XU Dexin, LIU Jiafu, CHEN Xinfu. Expression of DNAJB4 and association with immune infiltration and prognosis in non-small cell lung cancer [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(6): 467-472.
[12]	. [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(6): 473-476.
[13]	. [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(6): 485-488.
[14]	ZHANG Qi, WU Jing, ZHANG Chenlu. The biological function and mechanism of ribonucleotide reductase subunit M2 in medulloblastoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(4): 279-284,291.
[15]	ZHUANG Xibing, YUAN Sujuan, ZHANG Qi, LU Minghe, CHENG Yunfeng, QIAO Tiankui. Antitumor effects of heparanase silencing plus nadroparin and the mechanisms in lung cancer cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(6): 413-420.