乳癌组织中C - erbB - 2 基因扩增与临床关系的研究

doi:10.3969/j.issn.1004-616x.1998.06.005

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (6): 349-351.doi: 10.3969/j.issn.1004-616x.1998.06.005

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STUDY ON THE AMPLIFICATION OF C-erbB-2 ONCOGENE IN BREAST CANCER

Chen Senqing , Zhao Xiangsheng , Ma Guojian , et al

Jiangsu Instit ute of Cancer Research , Nanjing 　210009

Received:1900-01-01 Revised:1900-01-01 Online:1998-11-30 Published:1998-11-30

Abstract

Abstract: Differential PCR was used to detect the variance of C - erbB - 2 gene copies in 63 fresh breast cancer tissues. Amplification of C - erbB - 2 oncogene was found in 13 of 63 breast cancer (20. 6 %) . The rate of amplification of C - erbB - 2 gene in patient s with positive lymph node metastasis was approximately equal to that in negative node patient s. It was identified that amplification of C - erbB - 2 gene existed in 5 of 17 on stage Ⅲ, 1 of 4 on stage Ⅳ, higher than that of stage Ⅱ (4/ 27) and stage Ⅰ(0/ 2) , but the difference was not significant ( P > 0. 50) .

Key words: Differential PCR, C - erbB - 2, Breast cancer

Chen Senqing , Zhao Xiangsheng , Ma Guojian , et al. STUDY ON THE AMPLIFICATION OF C-erbB-2 ONCOGENE IN BREAST CANCER[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1998, 10(6): 349-351.

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STUDY ON THE AMPLIFICATION OF C-erbB-2 ONCOGENE IN BREAST CANCER

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