强化全营养乳对环磷酰胺致突变和移植性肿瘤的抑制作用

doi:10.3969/j.issn.1004-616x.1999.01.010

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (1): 28-031.doi: 10.3969/j.issn.1004-616x.1999.01.010

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THE INHIBITORY EFFECT OF FORTIFIED FULL2NUTRITIONAL MILK ON MUTAGENICITY INDUCED BY CYCLOPHOSPHAMIDE AND TRANSPLANTED TUMOR IN MICE

Tian Qingwei, Wang Yongming, Wang Wei, Wang Dusheng, Jin Ling

College of Public Health, Tianjin Medical University, Tianjin 　300070

Received:1997-12-11 Revised:1998-06-07 Online:1999-01-30 Published:1999-01-30

Abstract

Abstract: The mice bone2marrow polychromatic erythrocytes (PCE) micronucleus test in vivo to check the antimutagenic effect of fortified full2nut ritional milk (FFNM) on mutagenicity induced by cyclophosphamide (CP) was carried out and anticarcinogenic potentials of FFNM on t ransplanted sarcoma S180 , bladder carcinoma and Ehrlich ascites carcinoma in mice were tested. The experimental result s indicated that FFNM with preventive administ ration significantly inhibited CP induced bone2marrow micronucleus formation in mice , which suggest that FFNM exhibited a protective effect on mutageninduced chromosomal breakage , i. e. it have a antimuta genic action. In addition , to a certain degree , FFNM might inhibit growth of t ransplanted substantive tumor.These result s suggested that FFNM might be of potential value in it s clinical applications.

Key words: fortified full-nut ritional milk, antimutagenic effect, micronucleus test, transplanted tumor

Tian Qingwei, Wang Yongming, Wang Wei, Wang Dusheng, Jin Ling. THE INHIBITORY EFFECT OF FORTIFIED FULL2NUTRITIONAL MILK ON MUTAGENICITY INDUCED BY CYCLOPHOSPHAMIDE AND TRANSPLANTED TUMOR IN MICE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(1): 28-031.

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THE INHIBITORY EFFECT OF FORTIFIED FULL2NUTRITIONAL MILK ON MUTAGENICITY INDUCED BY CYCLOPHOSPHAMIDE AND TRANSPLANTED TUMOR IN MICE

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