L5178Y和WTK1 细胞微核试验在诱变测试中的应用

doi:10.3969/j.issn.1004-616x.1999.03.011

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (3): 140-143.doi: 10.3969/j.issn.1004-616x.1999.03.011

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APPLICATION OF IN VITRO MICRONUCLEUS TEST USING L5178Y AND WTK1 CELLS TO MUTAGENICITY ASSAY

Lv Xiaohua 　Zhang Lishi 　Wang Ruishu

Department of N ut rition and Food Hygiene , West China University of Medical Sciences , Chengdu 　610041

Received:1998-06-30 Revised:1998-11-24 Online:1999-05-30 Published:1999-05-30

Abstract

Abstract: A series of model mutagens were systematically tested with the in vit ro micronucleus test using established L5178Y mouse lymphoma and WTK1 human lymphoblastoid cell lines. The results showed that the in vit romicronucleus assay using L5178Y and WTK1 cells was simple and sensitive ,and it could be beneficial to improve the accuracy of screening mutagens when these two cell lines were simultaneously applied to a shortterm assay system.

Key words: micronucleus test, L5178Y cells, WTK1 cells, mutagens

Lv Xiaohua 　Zhang Lishi 　Wang Ruishu. APPLICATION OF IN VITRO MICRONUCLEUS TEST USING L5178Y AND WTK1 CELLS TO MUTAGENICITY ASSAY[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(3): 140-143.

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APPLICATION OF IN VITRO MICRONUCLEUS TEST USING L5178Y AND WTK1 CELLS TO MUTAGENICITY ASSAY

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