Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (1): 50-51.doi: 10.3969/j.issn.1004-616x.2004.01.015

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Study on the Inhibitory Affection of Maifanshi Soak Solution on Micronucleus in Root Tip Cells of vicia faba Caused by Alcohol and Cigarette Smoke

NAN Xiao-guang   

  1. Clinical Medical College,Inner Mongolia univrsty for Nationalities,Tongliao 028041,China
  • Received:2003-07-14 Revised:2003-08-28 Online:2004-01-30 Published:2004-01-30
  • Contact: NAN Xiao-guang

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Abstract: BACKGROUND ＆ AIM:To study the affection of Chinese maifanshi (CMFS) on genetic toxicity induced by alcohol and cigarette smoke .MATERIAL AND METHODS: Adding CMFS (160 mg/L) in the combined solution of wine alcohol(3％) and cigarette smoke (1 cigarette/100 ml)and then using the technique of micronucleus in root tip cells of Vicia faba to detect the micronuclei frequency(MNF).RESULTS: MNF caused by the alcohol and cigarette smoke was( 172.67±10.69) ‰.It was significantly higher than(P< 0.01) that (24.67±4.04)‰ caused by wine alcohol (3 ％) alone or that (154.00±5.05)‰ caused by cigarette smoke (1 cigarette/100 ml)alone.The MNF (12.33±5.05) ‰ caused by alcohol and cigarette smoke and CMFS was significantly (P<0.01) lower than that caused by alcohol and cigarette smoke. CONCLUSION: The cumulative effect on genetic toxicity induced by alcohol (3 ％) and cigarette smoke (1 cigarette/100 ml) was observed.The solution of CMFS (160 mg/L) can decrease the micronuclei frequency in root tip cells of Vicia faba.

Key words: Maifanshi, alcohol, cigarette smoke, micromucleus, anti-mutation