蜂胶乙醇提取物基因抗突变作用的研究

doi:10.3969/j.issn.1004-616x.2005.01.013

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2005, Vol. 17 ›› Issue (1): 39-40.doi: 10.3969/j.issn.1004-616x.2005.01.013

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Antagonistic Effect of Propolis on Mutation Induced by Thiotepa，Adriacin and Acridine Orange

WANG Ju-xiang;PEI Shi-geng;MEN Jin-e;et al

Derparment of Hygien ,Hebei Engineering College, Handan 056029,China

Received:2004-04-12 Revised:2004-08-29 Online:2005-01-30 Published:2005-01-30
Contact: WANG Ju-xiang

Abstract

Abstract: BACKGROUND ＆ AIM: To study the antagonistic effect of propolis on gene_mutation induced by thiotepa and other strong mutagens. MATERIAL AND METHODS: Using Ames_test,the antagonistic effect of propolis to reverse mutation of strains TA100 and TA98,which induced by thiotepa,adriacin and acridine orange,were assessed.RESULTS:The propolis inhibited all the mutations induced by the three kind of mutagens and showed dose_effect relationship. Dose of 10～250 μg/plate of propolis could inhibit mutations by the middle intensity or below (restrain rate<75 ％).At dose of 1 000 μg/plate of propolis could strongly inhibit mutations induced by thiotepa,adriacin, and acridine orange.There were no mutant character of the propolis. CONCLUSION： There were antagonistic effect of propolis to gene_mutation induced by different kinds of mutagen,such as adriacin.

Key words: propolis, mutagen, Ames test, gene mutation

WANG Ju-xiang, PEI Shi-geng, MEN Jin-e, et al. Antagonistic Effect of Propolis on Mutation Induced by Thiotepa，Adriacin and Acridine Orange[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2005, 17(1): 39-40.

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Antagonistic Effect of Propolis on Mutation Induced by Thiotepa，Adriacin and Acridine Orange

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