Carcinogenesis, Teratogenesis & Mutagenesis ›› 2007, Vol. 19 ›› Issue (1): 47-049.doi: 10.3969/j.issn.1004-616x.2007.01.014

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Preliminary Study of Inheritable Toxicity of 1,2-dimethyl-3- hydroxypyrid-4-one in Mice

WU Shi-de1,LIU Ping2,,FENG Guo-chang2，ZHUO Jin-hua2,YAO Yu-na2   

  1. 1.Institute of Shandong Biological Medicines,Jinan 250014, China; 2.Department of Health Surveillance, College of Public Health,Shandong University,Jinan 250012, China
  • Received:2006-02-15 Revised:2006-05-30 Online:2007-01-30 Published:2007-01-30

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Abstract: BACKGROUND ＆ AIM: To investigate the acute toxicity and the inheritable toxicity of 1,2-dimethyl-3- hydroxypyrid-4-one(DHPO) in mice. MATERIALS AND METHODS: LD50 test was performed ,then Kun Ming mice were given different oral doses of the DHPO to carry out the micronucleus test under low(1/8 LD50), mid (1/4 LD50), high(1/2 LD50) doses. RESULTS: LD50 of DHPO was 562.34 mg/kg peroral in mice. 1/2 LD50 group was different from the negative control in the micronucleus test(P<0.05), whereas no significant differences were observed among 1/4 LD50 , 1/8 LD50 groups and negative control(P>0.05). CONCLUSION: Our results suggested that DHPO had low toxicity but had inheritable toxicity to a certain extent.

Key words: DHPO, LD50, polychromatic erythrocyte, micronucleus test

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