Abstract: BACKGROUND ＆ AIM: To study the inhibitory effect of extracts of digestive gland on tumor cells using the mice tumor model. MATERIALS AND METHODS: Tumor cells of H22, S180 and MGC-803 were transplanted into mice，the extract was given through the gastrointestinal tract continuously,and the volume of the tumor was measured at different stages. RESULTS: After treatment with the digestive gland extract, the tumor development velocity in tumor bearing mice decreased significantly, and the tumor volume was markedly reduced. The tumour proliferation ratio was less than 60％,the tumor volume reduction ratio was more than 43.7％, and the tumor weight was decreased significantly after different doses of the extracts. CONCLUSION: Extract of digestive gland has obvious suppressive effect on tumor development.

Key words: biology produce, digestive gland, anti-tumor, drug effect