Abstract: To study the antagonistic effects of vitamin A and vitamin E against Co60 radiation-induced oxidative injury. METHOD：Experiment 1：Rats were divided into five groups，including control， radiation，radiation + vitamin A，radiation + vitamin E and radiation + half dose of vitamin A and vitamin E. Before exposure to radiation， rats were treated with intragastrically with 30 mg/kg vitamin A，30 mg/kg vitamin E，or 15 mg/kg vitamin A + 15 mg/kg vitamin E. Experiment 2：Rats were divided into seven groups，including control， radiation，radiation + 30 mg/kg vitamin E，radiation + 30 mg/kg vitamin E + different concentrations of vitamin A，ranging from 2.5 mg/kg to 20 mg/kg. Before the exposure to radiation，rats received intragastrically 30 mg/kg vitamin E，or 30 mg/kg vitamin E + different concentration of vitamin A. At day 7，rats were exposed to 6 Gy Co60 radiation. At day 10，the rats were sacrificed，and serum and tissues were collected for analysis. RESULTS：Vitamin A and vitamin E alone could protect the rats against the injury induced by radiation. When the concentration of vitamin E was fixed at 30 mg/kg，different concentrations of vitamin A resulted in the increase of MDA，the decrease of SOD and CAT activities and the content of vitamin E，in a dose-dependent manner. CONCLUSION：Under certain concentration，vitamin A and vitamin E could produce antagonistic effect.

Key words: vitamin A, vitamin E, radiation, MDA, SOD, CAT