Carcinogenesis, Teratogenesis & Mutagenesis ›› 2007, Vol. 19 ›› Issue (5): 406-408.doi: 10.3969/j.issn.1004-616x.2007.05.017

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Follow up of the Cytogenetics on 6 Victims Exposed to 60Co Radiation Accident in Henan

HAN Lin1，DUAN Guo_lu2，Wang Xi_ai1，ZHAO Yang_hui2，FU Bao_hua1，ZHAO Feng_ling1 ，LU Yu_min1，3,   

  1. (1.Henan Institute of Occupational Medicine, Zhengzhou 450052;2.Luoyang Instiurte of Environmental Inspection,Luoyang 471000;3. Public Health College of Zhengzhou University, Zhengzhou 450052，China)
  • Received:2006-10-08 Revised:2006-12-13 Online:2007-09-30 Published:2007-09-30
  • Contact: LU Yu_min

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Abstract: BACKGROUND ＆ AIM: Follow up cytogenetic tests was performed on the 6 victims exposed to 60Co radiation accident in Henan. MATERIALS AND METHODS: The samples of chromosome and CB micronucleus were prepared by using cultured whole blood, and analysis of chromosomal aberrations and CB micronuclei were made in the 6 victims exposed to 60Co radiation accident occurred in Xinxiang of Henan 1_2 years after irradiation. RESULTS： The frequencies of chromosomal aberrations in the victims had obviously declined in 1_2 years after irradiation. The proportion of unstable chromosomal aberration was higher in 1 year, and the rate of stable chromosomal aberrations was greater than that of unstable 2 year after irradiation. Frequencies of CB micronuclei in the victims had mostly declined into the background range in 1_2 years after irradiation. CONCLUSION： The results suggested that unstable chromosomal aberrations had gradually resolved, and stable chromosomal aberrations was still the majority as time progressed after irradiation. Late genetic effects of individuals exposed to high_dose irradiation can not be evaluated by analysis of CB micronucleus.

Key words: 60Co radiation accident, chromosomal aberration, CB micronucleus, follow up observation

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