Abstract: BACKGROUND AND AIM： To investigate the expressions of heat shock protein 27(HSP27) and trefoil factors2 (TFF2) in gastric cancer and precancerous condition and its correlation with helicobacter pylori(Hp) infection. MATERIALS AND METHODS： The expressions of HSP27 and TFF2 and the infection of Hp were studied by immunohistochemical methods in 140 gastric specimens including 25 chronic superficial gastritis(CSG), 30 gastric ulcer (GU), 35 chronic atrophic gastritis (CAG) and 50 gastric cancers (GC). RESULTS： In CSG,GU,CAG and GC, the expressions of HSP27,TFF2 and Hp were increased, but the expression of TFF2 was decreased in gastric cancer. The expression of HSP27 in Hp positive group was significantly higher than that in negative group. The expression of HSP27 was positively correlated with the infection of Hp (r=0.235,P<0.05).The expression of TFF2 in Hp positive group was significantly decreased compared with that in negative. The expression of TFF2 was negatively correlated with Hp infection (r=－0.259,P<0.05). CONCLUSION： HSP27,TFF2 and Hp may play important roles in carcinogenesis and progression of gastric carcinoma. The evaluation of HSP27 and TFF2 and Hp could provide theoretical basis for diagnosing, evaluating prognosis and guiding treatment of gastric cancer.

Key words: heat shock protein 27, trefoil factors2, helicobacter pylori