Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (1): 28-030.doi: 10.3969/j.issn.1004-616x.1998.01.009

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THE EFFECTS OF SODIUM FLUORIDE ON THE UV ABSORPTION SPECTRUM OF DIFFERENT TYPES OF DNA

Gao Xibao , Liu Chunsheng , Sun J ianxia , Zhang Ning , Xu Zhi , Li J ie   

  1. School of public heal th , S handong Medical University , Jinan 250012
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-01-30 Published:1998-01-30

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Abstract: The direct combination of sodium fluoride(NaF) to the different types of DNA was investigated using UV absorption spect romet ry. The result s showed that NaF (0. 15 - 23. 6mmol/L) could significantly change the UV absorption spect rum of the linar type fetal bovine thymus DNA (22. 4 mg/ L) and Lamds DNA(0. 9mg/ L) . It s absorption peak was shifted and declined.NaF (10 - 80 mmol/ L) could not change the UV absorption spect rum of the circular type PBR322DNA. These may explain the result s of that NaF induce clastogenicity and mutation in mammalian cell assays but not in bacteria mutation test s.

Key words: Fluoride, DNA combination, UV absorption spect rum.