Carcinogenesis, Teratogenesis & Mutagenesis ›› 2007, Vol. 19 ›› Issue (2): 113-115.doi: 10.3969/j.issn.1004-616x.2007.02.009

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Correlation of NF-κB and COX-2 Expressions in Cervical Cancer with HPV16 Infection

LIN Qiao-ai1, CHEN Xiang-min2, XIA Ke-dong1, DONG Hai-yan1, CHEN Shao1, ZHANG Li-fang1   

  1. 1.Department of Microbiology and Immunology, Wenzhou Medical College , Wenzhou 325027, Zhejiang,China;2. Central Laboratory of Biology, Wenzhou Medical College, Wenzhou 325027, Zhejiang, China
  • Received:2006-03-22 Revised:2006-11-15 Online:2007-03-30 Published:2007-03-30
  • Contact: LIN Qiao-ai

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Abstract: BACKGROUND ＆ AIM: To explore the relationship between expressions of NF-κB and COX-2 in tissue of cervical cancer and HPV16 infection. MATERIALS AND METHODS: The expressions of NF-κB and COX-2 were assessed by immuohistochemical staining in 46 specimens of cervical cancer and 31 specimens of normal cervical tissue. The infection of HPV16 DNA were determined by PCR. RESULTS: The expression rates of NF-κB and COX-2 in cervical cancer appeared significantly higher than that in normal cervical tissue(P<0.01).The expressions of NF-κB and COX-2 in HPV DNA positive group were significantly higher than that in negative group(P<0.05) of cervical cancer. CONCLUSION: There were higher expressions of NF-κB and COX-2 in cervical carcer tissues. The activation of NF-κB and overexpression of COX-2 may be related to HPV 16 infection.

Key words: cervical cancer, NF-κB, cyclooxygenase-2, HPV16

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