伊痛舒的致突变作用研究

doi:10.3969/j.issn.1004-616x.1999.01.015

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (1): 42-043.doi: 10.3969/j.issn.1004-616x.1999.01.015

Previous Articles Next Articles

STUDY ON MUTTAGENICITY OF YI TONG SHU

Xu Dexiang, Sun Meifang, Wei Lingzhen, etal

Dept. of Toxicology, Anhui Medical University, Hefei 　230032

Received:1998-02-05 Revised:1998-06-10 Online:1999-01-30 Published:1999-01-30

Abstract

Abstract: Yi Tong Shu, a Chinese medicine, was examined for mutagenicity with cultured CHL cell chromosome aberration test , Ames test and micronucleus test of PCE in mouse bone marrow. The result s showed that Yi Tong Shu with 5 doses (0. 00625ml/ plate - 0. 1ml/ plate) didn’t increase the reversion mutation frequencies in st rain TA97 , TA98 , TA100 and TA102 with or without S9 in the Ames test ; It didn’t increase the frequencies of micronucleus in PCE and chromosome aberrations in CHL cells.

Key words: Yi Tong Shu, Chinese medicine, Mutagenicity

Xu Dexiang, Sun Meifang, Wei Lingzhen, etal. STUDY ON MUTTAGENICITY OF YI TONG SHU[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(1): 42-043.

[1]	GE Xianmin, LI Bin, HUANG Chaopei, GAO Yuqiu, LUO Hailan, YANG Hui, WANG Yanwu, WEN Pingjing, LAN Guanghua, CHEN Huanhuan, MENG Qin, LUO Liuhong, DENG Yueqin, LIU Shuaifeng, WU Xiuling. Acute oral toxicity and mutagenicity of combined drugs for anti HIV [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 466-469,474.
[2]	HUANG Chaopei, QIN Huiyan, ZHANG Lujuan, WANG Yanwu, HE Li, FU Weizhong. Study on acute toxicity and mutagenicity of Aronia melanocarpa extract in mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 474-476.
[3]	ZHENG Kai, WANG Bingyu, XU Xinyun, GENG Hong, HUANG Haiyan, LIU Wei, LONG Dingxin. Mutagenicity of PM_2.5 samples from Shenzhen and Taiyuan [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(6): 483-487.
[4]	LIN Lin, FAN Xiaoyu, LI Encan, LING Yahao, ZANG Qingce, LIN Sheng, HE Jiuming, JIN Hongtao. Potential immunotoxicity of three traditional Chinese medicines using the popliteal lymph node assay in mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(4): 275-278,285.
[5]	JIANG Yi, JIA Xiaohui, LI Peining, CHEN Xiujuan, LIU Donghong, LIU Xiangmei. Ames mutagenicity assay on five plastic surface chemicals in racetrack [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(4): 309-312.
[6]	YUAN Ye, CHEN Dandan, JING Shufang, YU Yongsheng, CHEN Jianheng, WU Chunqi, SHI Chang. Mutagenic effects of N-(n-butyl)-thiophosphorictriamide in somatic and germ cells of mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(6): 432-437.
[7]	CAO Yiyi, LIU Qian, XI Jing, MA Leilei, LIU Xiaojian, LUAN Yang. Comparative evaluation of mutagenicity of four aristolochic acids components using the Ames fluctuation test [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(5): 398-402.
[8]	TANG Jiao, ZHAO Min, YANG Ying, LI Qing, HUANG Junming, YANG Xingfen. Study on acute toxicity and mutagenicity of Panaxnotoginseng [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(1): 66-68,72.
[9]	YAN Jiuming, YUE Qianlan, JIA Zhenchao, LI Yan, ZHANG Lishi. General toxicity and mutagenic effects of Mulberry-Astragalus capsule [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(6): 472-476.
[10]	BAO Jie, WEI Jinfeng, WANG Xiaoliang, LI Haiyan, ZOU Na, WANG Aiping. Studies on acute toxicity and mutagenicity of potassium 2-(1-hydroxypentyl)-benzoate [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(2): 137-141.
[11]	ZHONG Yuting, JIA Zhenchao, YAN Jiuming, LUO Sha, LU Yedan, ZHANG Lishi. Study of acute toxicity and mutagenicity of bamboo charcoal powder [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(2): 142-145.
[12]	CHEN Ying，LI Ying，GUAN Jun，WANG Zhong-hui，JIA Yu-ling，ZHOU Li，SUN Zu-yue*. Optimization of standardized Ames fluctuation test [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2014, 26(3): 199-203.
[13]	WANG Chong，HOU Juan，HAN Jing，RUI Jing *. The safety and anti-mutagenicity of total terpene ketones from Swertia mussotii [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2014, 26(3): 221-224.
[14]	ZHANG Jian-jun，JIANG Ling，ZHANG Hai-jiao，CHAI Zhen-hai*. Effects of the ethylene oxide-sterilized Petri plate on Ames test [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2014, 26(3): 228-230.
[15]	LI Shu-qin，LI Jian-guo，LI Xue-min，BIAN Lin-xiu. Acute toxicity and mutagenicity test of Chia seed [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2013, 25(6): 470-473.

STUDY ON MUTTAGENICITY OF YI TONG SHU

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments