Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (1): 46-048.doi: 10.3969/j.issn.1004-616x.1999.01.017

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STUDY ON THE MUTAGENICITY OF DOXAZOSIN

Xu Dexiang, Wei Lingzhen, Sun Meifang, etal   

  1. Dept. of Toxicology , Anhui Medical University, Heifei  230032
  • Received:1998-02-05 Revised:1998-06-10 Online:1999-01-30 Published:1999-01-30

Abstract: Doxazosin , a new antihypertensive agent , was examined for mutagenicity with cultured CHL cell chromosome aberration test , Ames test and micronuclcus test of PCE in mouse bone marrow. The results showed that doxazosin with 5 doses (312. 5ug/ plate - 5 000μg/ plate) didn’t increase the reversion f requencies in st rain TA97 , TA98 , TA100 and TA102 with or without S9 in the Ames test ; It didn’t increase the f requencies of micronucleus in PCE and chromosome aberrations in CHL cells.

Key words: Doxazosin, Mutagenicity