维吾尔族妇女宫颈癌患者的免疫状态及其与临床病理因素的关系

doi:10.3969/j.issn.1004-616x.2016.05.007

Abstract

Abstract: OBJECTIVE: The aim of this study was to investigate the association between IL-2 and IL-10 cytokine levels in plasma,and clinical pathologic factors in cervical cancer of Uighur women. METHODS: Peripheral blood specimens from 50 cervical cancer patients,20 patients with CIN Ⅲ precancerous lesions and 18 controls were used to detect IL-2 and IL-10 by ELISA. RESULTS: The results show that expressions of IL-2 in plasma from patients with cervical cancer or precancerous lesions was significantly reduced compared with those from the controls (P<0.05),while expressions of IL-10 was significantly increased (P<0.05). From the cervical cancer group,IL-10 expression was gradually increased with tumor pathological staging (P<0.05),while IL-2 expression level did not show obvious relationship with tumor pathological staging (P>0.05). Moreover,there was no significant difference in IL-2 expression (P>0.05) between normal Han and Uighur populations,but among those with cervical cancer,Uighur patients' IL-2 expression level was significantly lower than that in Han patients (P<0.05). CONCLUSION: Our results show that immunosuppression occurred despite having low cellular immune level among cervical cancer patients. The observation suggests that one of the mechanisms may be immune escape of tumor cells. In addition,IL-2 may have played an important role in cervical carcinogenesis among Uighur women.

Key words: cervical cancer, IL-2, IL-10, enzyme linked immunosorbent assay, immune level

CLC Number:

R737.33

SHENG Lei, RU Mingfang, WU Guizhen, YANG Yun, ABUDULA·Abulizi. Association between immune state and clinical pathologic parameters in cervical cancer of Uighur women[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(5): 369-371,376.

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Association between immune state and clinical pathologic parameters in cervical cancer of Uighur women

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