刺山柑果风湿止痛凝胶膏对SD大鼠胚胎-胎仔发育的影响

doi:10.3969/j.issn.1004-616x.2024.05.011

Abstract

Abstract: OBJECTIVE： To investigate effects of the Capparis spinosa fruit rheumatism pain relief gel on embryo-fetal development in SD rats. METHODS： Rats were divided into Capparis spinosa fruit rheumatism pain relief gel high (117.8 g/m²)，medium (58.9 g/m²)，low (29.5 g/m²) dose groups，excipient control group (excipient paste) and positive control group (cyclophosphamide). The drug was given once a day from the 6^th to 15^th days after pregnancy，and the positive control group was injected subcutaneously with cyclophosphamide on GD12. The general condition，body weight and feed consumption of pregnant rats were observed during the experiment. The pregnant rats were sacrificed on GD20，and the fetuses were taken to check the uterine combined fetal weight，luteal number，implantation number，fetal weight，fetal body length，fetal tail length，live birth number，dead birth number，absorbed birth number，fetal gender and appearance，visceral and skeletal malformation. RESULTS： There were no significant differences in body weight，body weight gain，food intake，uterine combined fetal weight，uterine and ovarian organ weight and its coefficient，average luteal number，loss rate before implantation，average implantation number，implantation rate，average live birth number，live birth rate，dead birth rate，absorbed birth rate，fetal gender ratio，fetal appearance abnormality rate，litter weight，litter body length，litter tail length，skeletal malformation rate and visceral malformation rate between the pregnant rats in the different dose groups of Capparis spinosa fruit rheumatism pain relief gel and the excipient control group (all P>0.05). CONCLUSION： The no-adverse reaction level of capsicum frutescens rheumatism pain relieving gel on embryo-fetal development of SD rats was 117.8 g/m²，which was 12 times of the body surface dose to be used in clinic. Under the conditions of this study，transdermal administration of capsicum frutescens rheumatism pain relieving gel on embryo-fetal development of SD rats had no toxic effect.

Key words: Capparis Spinosa fruits pain gel, SD rats, embryon-fetal development, reproductive toxicity

CLC Number:

Q355
R394.6

XU Wenli, LI Shufang, MANERBAHA·Hairula, WANG Xingang, CHENG Bo, LIU Huan, SUN Ge, YUAN Hui, YANG Weijun. Effect of Capparis spinosa fruits pain gel paste on embryo-fetal development of SD rats[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2024, 36(5): 399-404.

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Effect of Capparis spinosa fruits pain gel paste on embryo-fetal development of SD rats

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