绝经后妇女尿液中微量元素与骨质疏松症的相关性研究

doi:10.3969/j.issn.1004-616x.2025.06.007

Abstract

Abstract: OBJECTIVE：To investigate associations between urinary trace elements and osteoporosis risk in postmenopausal women in Shenzhen. METHODS：Based on a cross-sectional study，3 667 postmenopausal women were selected from the Shenzhen Aging-Related Diseases Cohort as participants. Demographic characteristics were collected via standardized questionnaires，and calcaneal bone mineral density (BMD) was assessed using quantitative ultrasound. Urinary concentrations of 20 trace elements were measured by inductively coupled plasma mass spectrometry (ICP-MS)，with all assays undergoing rigorous quality control. Multivariable logistic regression and quantile-based g-computation were employed to evaluate associations between urinary trace element levels and osteoporosis risk. RESULTS：Chromium (Cr)，copper (Cu)，zinc (Zn)，selenium (Se)，molybdenum (Mo)，vanadium (V)，lithium (Li)，titanium (Ti)，rubidium (Rb)，tin (Sn)，and barium (Ba) showed positive associations with osteoporosis risk (OR=1.41，2.33，1.35，1.36，1.34，1.62，1.07，2.39，1.42，1.48，and 1.56，respectively；all P<0.01). In contrast，cobalt (Co) and antimony (Sb) were negatively associated with osteoporosis risk (OR=0.80 and 0.81，respectively；P<0.01). Mixed-effect analysis revealed statistically significant joint effects of essential trace elements and potentially essential trace elements on osteoporosis risk (OR=1.15 and 1.13，respectively；P<0.01). CONCLUSION：This study found that different trace elements exerted distinct associations with osteoporosis risk in postmenopausal women，suggesting that imbalances in trace element metabolism may play a significant role in the pathogenesis of osteoporosis.

Key words: postmenopausal women, trace element, metabolism, osteoporosis

CLC Number:

R181

YE Mingqi, ZHOU Tao, LIU Peiyi, LUO Yi, LIU Jianjun, HUANG Zhenlie, REN Xiaohu. Association between urinary trace elements and osteoporosis in postmenopausal women[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2025, 37(6): 467-472.

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Association between urinary trace elements and osteoporosis in postmenopausal women

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