8-Br-cAMP 诱导人食管癌细胞凋亡的研究

doi:10.3969/j.issn.1004-616x.2000.02.017

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (2): 113-114.doi: 10.3969/j.issn.1004-616x.2000.02.017

Previous Articles Next Articles

THE EFFECT OF 8 - Br - cAMP ON APOPTOSIS IN HUMAN ESOPHAGEAL CANCER CELL LINE

HU Jie-ying1 , JANG Dong-xia1 , SHAN Juan2

1. Henan Tumor Instit ute , Zhengz hou 　450003 , China 　2. Henan Tumor Hospital , Zhengz hou 　450003 , China

Received:1999-07-27 Revised:1999-11-30 Online:2000-04-30 Published:2000-04-30

Abstract

Abstract: Purpose and Methods : The occurrence of apoptosis induced by 8 - Br - cAMP was studied in human Eca - 109 cell line and by means of TUNEL method. Results : The spontaneus apoptosis f requency of human Eca - 109 cells was 10. 3 %. The apoptosis f requency of Eca - 109 cells t reated with 8 - Br - cAMP was 33. 2 %. There was statistical significant difference between the cont rol group and 8 - Br - cAMP induced group. Conclusion : The result s indicated that 8 - Br - cAMP could possess the tendency of increase apoptosis f requency inhuman Eca - 109 cell line.

Key words: apoptosis, 8 - Br - cAMP, Eca - 109 cell line

CLC Number:

Q730. 23

HU Jie-ying , JANG Dong-xia , SHAN Juan. THE EFFECT OF 8 - Br - cAMP ON APOPTOSIS IN HUMAN ESOPHAGEAL CANCER CELL LINE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2000, 12(2): 113-114.

[1]	LI Boru, QIN Shuangjian, GUAN Lan, LI Runbing, CAI Ying, PU Jiening, ZENG Ming, XIAO Fang, XU Xinyun. Effects of PM_2.5 on oxidative damage and apoptosis in HK-2 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 360-364.
[2]	HUANG Xiaohua, NIU Yongdong, SHI Ganggang. Inhibitory effects and mechanisms of nuclear receptor FXR activation in cervical cancer cell line CaSki [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(4): 302-306.
[3]	WANG Xikai, MENG Qinghe, GAO Yanlu. miR-223-3p negatively regulated ECT2 to induce apoptosis in non-small cell lung cancer cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(3): 187-192.
[4]	LI Boru, QIN Shuangjian, LI Runbing, CAI Ying, ZHENG Kai, ZENG Ming, XIAO Fang, XU Xinyun. Effects of p38MAPK gene on PM_2.5-induced expression of oncogenes and apoptosis genes in HK-2 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(2): 129-135,142.
[5]	MA Shunpeng, WANG Quankai, WANG Miao, SONG Jiayang, WUHAN Baolier, XIE Guangyun, XU Jianning. Long non-coding RNA regulates apoptosis during glycidyl methacrylate-induced malignant transformation of 16HBE cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 1-5,31.
[6]	LI Boru, QIN Shuangjian, LI Runbing, CAI Ying, ZHENG Kai, WANG Bingyu, ZENG Ming, XIAO Fang, XU Xinyun. Effects of PM_2.5 exposure on expression of oncogenes and apoptosis genes in human renal epithelial cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 6-11.
[7]	HUANG Lili, ZHANG Mengyun, LIU Keliang, PANG Dingguo, LIU Lida, XU Peiyu. Hepatotoxicity of 2,4-dichlorophenoxyacetic acid in young SD rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 22-27.
[8]	CUI Zhaoyang, LI Suna, JIANG Xuqian, WANG Yidan, HOU Liying. Activation of the TRAIL death receptor by apigenin for induction of apoptosis in the gastric cancer SGC-7901 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 32-36.
[9]	LAN Li, CHEN Haili, XU Lei. Mechanism of RBMS3-S3 on the proliferation, apoptosis and invasion of cervical cancer cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 438-443.
[10]	LIU Peng, BAI Yixiao. Effect of miR-29a on proliferation and migration of human gastric cancer cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 452-456,463.
[11]	YANG Xingxiao, ZHANG Xueyuan, ZOU Naiyi, SHAN Bao'en, MA Ming, ZHU Shuchai. Effect of HMGB1 silencing by siRNA on radiosensitivity of esophageal carcinoma KYSE30 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(4): 269-274.
[12]	QIN Shuangjian, LI Boru, CAI Ying, ZHENG Kai, WANG Bingyu, LI Runbing, XIAO Fang, ZENG Ming, XU Xinyun. PM_2.5 exposure on expression of oncogenes and apoptosis genes in hepatocytes [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(4): 281-285.
[13]	CAI Ying, ZHENG Kai, QIN Shuangjian, LI Boru, YU Shuyuan, LIU Ning, JI Jiajia, ZHANG Zhaohui, XU Xinyun. Silencing of c-fos gene on expression of oncogenes and apoptosis genes in HBE cells exposed to PM_2.5 [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(4): 298-303,308.
[14]	HUA Chenfeng, ZHAO Junwei, SHANG Pingping, FAN Meijuan, XIE Fuwei, LI Xiang. Induction of cytotoxicity, inflammatory factor release and apoptosis by cigarettes with different tar releases [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(3): 182-186.
[15]	WANG Yaojie, XIANG Xiaohan, HAN Lina, LI Jun, HUO Bingjie, ZHAO Lianmei. Inhibitory effects of ethanol extract from Euphorbia humifusa on gastric cancer cells in vitro [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(3): 187-193.

THE EFFECT OF 8 - Br - cAMP ON APOPTOSIS IN HUMAN ESOPHAGEAL CANCER CELL LINE

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments