Carcinogenesis, Teratogenesis & Mutagenesis ›› 2001, Vol. 13 ›› Issue (3): 147-150.doi: 10.3969/j.issn.1004-616x.2001.03.004

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ANTITUMOR EFFECT AND MECHANISMS OF ZHENXIANG CAPSULE ON HUMAN ESOPHAGEAL CARCINOMA

XU Jin-jie1, XU Xiao-hu1, WANG De-chang2, ZEN G Xian-ming3   

  1. 1. Department of Pathology and Pathophysiology Shantou University Medical College , Shantou 515031 ,China ; 2. Department of Pharmacology , Institute Oncology , Chinese Academy of Medical Sciences , Beijing 100073 , China ; 3. Department of Experiment Animal Center , Sun Yat2sen University of Medical Sciences ,Guangzhou 510087 , China
  • Received:2000-09-19 Revised:2000-12-26 Online:2001-07-30 Published:2001-07-30

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Abstract: Purpose : To investigate the antitumor effect and mechanisms of Zhenxiang capsule (ZXC) on human esophageal carcinoma. Methods : Apoptosis induced by ZXC in human esophageal carcinoma cell line EC109 was investigated by optical microscopy , transmission elect ron microscopy and flow cytomet ry. Antitumor effect of ZXC was observed on human esophageal carcinoma xenograft in nude mice. Results : After exposure to ZXC ,EC109 cells manifested typical apoptotic features. The tumor2inhibiting rates in the groups of ZXC 4 800 mg/(kg·bw) , 2 400 mg/ (kg·bw) and 1 200 mg/ (kg·bw) ranged f rom 70. 80 % to 75. 00 %( P < 0. 01) , 58. 33 % to 64. 71 %( P < 0. 01) and 37. 04 % to 45. 10 %( P < 0. 01) , respectively. The tumor2inhibiting rates of the pingyangmycin (15 mg/ (kg·bw) ) group ranged f rom 51. 33 % to 60. 78 %( P < 0. 01) . Conclusion : ZXC induces apoptosis of esophageal carcinoma cells in vit ro , which is possibly the primary mechamism of ZXC inhibition of esophageal carcinoma. ZXC has significant antitumor effect on human esophageal carcinoma t ransplanted into nude mice at tolerant doses. The antitumor effect increases with dosage.

Key words: zhenxiang capsule, esophageal carcinoma, animal disease model, nude mouse

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