番茄红素对甲基戊基亚硝胺在大鼠中致癌性的影响

doi:10.3969/j.issn.1004-616x.2001.03.005

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2001, Vol. 13 ›› Issue (3): 151-153.doi: 10.3969/j.issn.1004-616x.2001.03.005

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EFFECT OF LYCOPENE ON CARCINOGENICITY OF N-METHYL-N-AMYLNITROSAMINE IN WISTAR RATS

ZHAN G Qing-ying1, HUANG Ge1, LUO Jia-yi1, SHEN Zhong-ying2, etal .

1. Department of Hygiene ; 2. Department of Pathology, Shantou University Medical College, Shantou 515031, China

Received:2001-01-19 Revised:2001-04-06 Online:2001-07-30 Published:2001-07-30

Abstract

Abstract: Purpose : To study the effect s of lycopene on the carcinogenicity of N2methyl2N2amylnit rosamine (MANA) in Wistar rat s. Methods : The rat s were randomly divided into three groups : simple MANA (M) ,MANA plus tomato jam (M + L P) and cont rol (C) groups. The experiment lasted 26 weeks. Histological examination was done and the levels of ROS unit , SOD , GSH2Px and MDA in the blood were determined. Results : There were precancerous lesions of esophagus or forestomach in the M and M + L P groups. The incidence of precancerous lesions in the M + L P group was decreased , and the levels of ROS unit , SOD , GSH2Px in the blood were higher , but the content of MDA was decreased. Conclusion : Lycopene may have an inhibitory effect on the carcinogenicity of MANA. The effect may be due to the inhibition of lipid peroxidation.

Key words: nitrosamine, esophageal cancer, lycopene, Wistar rat

CLC Number:

ZHAN G Qing-ying, HUANG Ge, LUO Jia-yi, SHEN Zhong-ying, etal .. EFFECT OF LYCOPENE ON CARCINOGENICITY OF N-METHYL-N-AMYLNITROSAMINE IN WISTAR RATS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2001, 13(3): 151-153.

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EFFECT OF LYCOPENE ON CARCINOGENICITY OF N-METHYL-N-AMYLNITROSAMINE IN WISTAR RATS

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