Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (1): 17-20.doi: 10.3969/j.issn.1004-616x.2003.01.005

Previous Articles     Next Articles

THE SIGNIFICANCE OF EXPRESSION OF hTRT AND C-myc IN ESOPHAGEAL EPITHELIOSIS AND CARCINOGENESIS

WU Ming-yao 1, WU Xian-ying 1, ZHUANG Chu-xiang 2   

  1. Department of Pathology, 2. Department of Physiology, Shantou University Medical College, Shantou, 515031 , China
  • Received:2002-07-10 Revised:2002-09-10 Online:2003-01-30 Published:2003-01-30
  • Contact: WU Ming-yao

PDF (PC)

2679

Abstract: Purpose: To investigate the expression of human telomerase reverse transcriptase (hTRT) and C-myc in esophageal epitheliosis and carconogenesis, and their relation to the development of esophageal carcinoma. Methods: Telomerase hTRT and C-myc protein expression in 70 fresh tissue specimen, including esophageal mucosa above the upper surgical margin, carcinoma in situ and mucosa adjacent to tumor, were detected using immunohistochemical method. Results: hTRT and C-myc protein were expressed in proliferating and transformed malignant cells of esophageal epithelium. The expression of C-myc protein showed a similar distribution pattern to that of hTRT. Conclusion: Telomerase hTRT and C-myc protein expressions are closely related to the malignant transformation of esophageal epithelium. The reactivated telomerase and up-regulated C-myc may play a crucial role in the development of esophageal carcinoma.

Key words: hTRT, C-myc, Esophageal epithelium, Carcinogenesis