Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (4): 217-219.doi: 10.3969/j.issn.1004-616x.2003.04.009

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STUDY ON EXPRESSION OF PTEN mRNA IN ENDOMETRIAL CARCINOMA

LI Chao, DAI Shu-zhen   

  1. Department of Obstetrics and Gynecology, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China
  • Received:2003-03-20 Revised:2003-04-30 Online:2003-10-30 Published:2003-10-30
  • Contact: LI Chao

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Abstract: Purpose: To investigate expression of PTEN mRNA in endometrial carcinoma and its clinocopathoopoology. Methods: The expression of PTEN mRNA was detected by reverse transcription-PCR in 65 endometrial carcinomas and 15 normal human endometria. Results: Of the 65 endometrial carcinoma cases, the loss of expressions of PTEN mRNA in exon 1-8 , exon 5-9 and exon 5-8 were 49.23 ％，38.46 ％ and 32.31 ％， respectively. Expressions of PTEN mRNA was detected in all of the normal endometrial tissues. The lost rate of expression of PTEN mRNA was significantly relevant to histological type and histological grade in endometrial carcinoma. Conclutions: There was a higher incidence of negative expression of PTEN mRNA in endometrial carcinoma, which indicates that PTEN gene inactivation may play an important role in the genesis and development of some endometrial carcinoma .

Key words: endometrial carcinoma, PTEN mRNA, RT-PCR