Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (3): 133-135.doi: 10.3969/j.issn.1004-616x.2000.03.002

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THE EFFECT OF NaF ON p16 GENE OF HUMAN EMBRYONIC LUNG FIBROBLAST CELLS

LIU Chun-sheng , MA Dao-xin   

  1. Hematology Instit ute , The A f f iliated Hospital of S handong Medical University , Jinan , 250012 , China
  • Received:1999-10-14 Revised:2000-01-04 Online:2000-07-30 Published:2000-07-30

Abstract: Purpose and Methods : To explore the genetic toxicity of NaF , we used PCR - SSCP and immunohistochemist ry methods to detect the effect s of NaF on p16 gene and P16 protein of human embryonic lung fibroblast (HEL F) cells. Results and Conclusion : The result s show that NaF can’t induce the change of p16 gene.

Key words: NaF, HEL F, p16 gene

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