Carcinogenesis, Teratogenesis & Mutagenesis ›› 2002, Vol. 14 ›› Issue (2): 84-086.doi: 10.3969/j.issn.1004-616x.2002.02.005

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EXPRESSION AND SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN IN RESISTANCE OF LITHIUM CARBONATE TO AFLATOXIN B1-INDUCED HEPATOCARCINOGENESIS IN RATS

LU Shuang1; ZHANG Ai-hua1; HUANG Xiao-xin2; Ren Yu-jiang2   

  1. 1. Department of Toxicology, Guiyang Medical College, Guiyang 550004, China; 2. Department of Gast roenterology, 44th Hospital of PLA, Guiyang 550009, China
  • Received:2001-04-11 Revised:2001-08-22 Online:2002-04-30 Published:2002-04-30
  • Contact: LU Shuang

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Abstract: Purpose and Methods : Using immunohistochemical assay , the expression and significance of proliferating cell nuclear antigen (PCNA) were studied in aflatoxin B1 hepatocarcinogenesis of Wistar rats treated with lithium carbonate (Li2CO3) . Results : The expression of PCNA occurred in the early stage of carcinogenesis and significantly increased at week 9 or 10. The positive rate of positive control group (B) was highest and that of group treated simultaneously (C) and group pretreated with Li2CO3 (D) significantly decreased , but group C was higher than group D. Conclusion : It suggested that Li2CO3 has the effect on anti-expression of PCNA in aflatoxin B1-induced hepatic carcinoma of the rat and can rest rain cell proliferation ,and that the immunohisto-chemical assay of PCNA may help early diagnosis and monitoring.

Key words: proliferating cell nuclear antigen, lithium carbonate, aflatoxin B1, hepatic carcinoma, Wistar rat

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