四川彝族人群HIV-1辅助受体CX3CR1基因多态性分析

doi:10.3969/j.issn.1004-616x.2006.06.002

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2006, Vol. 18 ›› Issue (6): 420-422.doi: 10.3969/j.issn.1004-616x.2006.06.002

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Genetic Polymorphism of HIV Coreceptor CX3CR1 Allele in Chinese Yi Ethnic Group in Sichuan

DENG Xiao-ling,HONG Kun-xue，CHEN Jian-ping,RUAN Yu-hua，XU Ming-yan，QIN Guang-ming，XING Hui，LI Ke，SHAO Yi-ming

(1. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050; 2. Department of Pathogenic Biology, Shantou University Medical College, Shantou 515041; 3. Center for Disease Control and Prevention of Sichuan Province, Chengdu 610003, China)

Received:2006-03-28 Revised:2006-07-06 Online:2006-11-30 Published:2006-11-30
Contact: SHAO Yi-ming

Abstract

Abstract: BACKGROUND ＆ AIM: To explore the CX3CR1 genetic polymorphisms in HIV-infected and uninfected Chinese Yi Ethnic Groups in Sichuan. MATERIALS AND METHODS: The genomic DNA of 202 Yi subjects (115 HIV-1 uninfected, 87 HIV-1 infected) was extracted from PBMCs. The V249I and T280 M allelic frequencies were identified by PCR-RFLP. All data were tested by χ2 analysis. RESULTS: Allelic frequencies of 249I and 280M in HIV-1 uninfected group were 8.3％ and 5.7％, respectively. The frequencies in HIV-1 infected group were 7.5％ and 5.7％, respectively. There was no significant difference between HIV-1 infected group and HIV-1 uninfected group, and both groups were in accordance with Hardy-Weinberg equilibrium. There are strong linkage disequilibrium between 249I and 280M of CX3CR1. CONCLUSION: Polymorphism of CX3CR1 allele from Chinese Yi Ethnic Group was found, this would be helpful for the risk analysis of HIV infection and the rate of HIV disease progression in Chinese Yi Ethnic Group in Sichuan.

Key words: HIV-1, receptors, CX3CR1, alleles, genetics polymorphism, mutation

CLC Number:

R512.91 R759

DENG Xiao-ling, HONG Kun-xue, CHEN Jian-ping, RUAN Yu-hua, XU Ming-yan, QIN Guang-ming, XING Hui, LI Ke, SHAO Yi-ming. Genetic Polymorphism of HIV Coreceptor CX3CR1 Allele in Chinese Yi Ethnic Group in Sichuan[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2006, 18(6): 420-422.

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Genetic Polymorphism of HIV Coreceptor CX3CR1 Allele in Chinese Yi Ethnic Group in Sichuan

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