Carcinogenesis, Teratogenesis & Mutagenesis ›› 2006, Vol. 18 ›› Issue (4): 292-293.doi: 10.3969/j.issn.1004-616x.2006.04.010

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Tributyltin Exposure Leads to Acetylcholinesterase Activity Elevation in Rat Brain

ZHU Xin1, LIAN Ling-jun1,WANG Yan1,LIU Hui-gang1,XU Li-hong1,2   

  1. 1.Institute of Occupational and Environmental Health, Zhejiang University Hang zhou 3100031,Zhejiang,China; 2.Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou 310031,Zhejiang,China
  • Received:2005-07-13 Revised:2005-11-02 Online:2006-07-30 Published:2006-07-30
  • Contact: XU Li-hong

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Abstract: BACKGROUND ＆ AIM: The study investigated the effect of tributyltin (TBT) on the activities of acetylcholinesterase(AChE)in brain of rats. The possible relationship between AChE and the toxicity of TBT was discussed. MATERIAL AND METHODS:48 SD rats were divided randomly into 4 groups,12 rats in each group.Experimental groups received 0.1,1 or 10 mg/kg TBT by oral gavage and same volume olive oil was given to control group(0 mg/kg TBT).The brain tissues were obtained from 4 rats in each group at the 4th,8th and 12th day and the AChE activities were measured. RESULTS: TBT exposure could lead to AChE activity elevation in rat brains, and in a dose-related and time-depending manner. CONCLUSION: The increase of AChE activity could possibly be related to the neurotoxicity of TBT.

Key words: tributyltin, acetylcholinesterase, neurotoxicity

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