Abstract: BACKGROUND ＆ AIM： To investigate the effects of haloperidol (Hal) on oocyte chromosomes in oogenesis. MATERIAL AND METHODS: Forty healthy female mice, 12 weeks-old, were randomly divided into four groups. The animals of different groups were exposed to Hal by intra-peritoneal injection of 0, 0.05, 0.50 and 5.00 mg/(kg•d) of Hal for successive 8 days, respectively. Oocytes were collected by superovulation and the metaphase were prepared for karyotypic analysis. RESULTS: For 0, 0.05, 0.50 and 5.00 mg/(kg•d) Hal-groups, the frequencies of hyperhaploid complements were 3.8 ％,4.4 ％,7.3 ％,18 ％，the frequencies of aneuploid complements were 7.5 ％,8.8 ％,14.5 ％,36.0 ％, the frequencies of degenerative oocytes were 1.3 ％,1.4 ％,1.8 ％,10.0 ％ and the mean number of splitting chromosomes were 0.013,0.014,0.018,0.100，respectively. Comparing all the experimental parameters of the 0.05 and 0.50 mg/(kg•d) Hal-groups with those of the control, no significant differences were observed (P>0.05). All the experimental parameters of 5.00 mg/(kg•d) Hal-group were higher than those of the control, and the differences of the parameters between two groups were statistically significant. CONCLUSION: A large-dose of Hal might be able to induce aneuploidy and degeneration of oocytes in oogenesis.

Key words: haloperidol, oocyte, aneuploidy, degeneration