Carcinogenesis, Teratogenesis & Mutagenesis ›› 2005, Vol. 17 ›› Issue (5): 284-286.doi: 10.3969/j.issn.1004-616x.2005.05.008

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Alcohol Dehydrogenase-2 Genotypes and Drinking Behavior of Chinese in Taixing City

CAO Hai-xia, DING Jian-hua, WU Jian-zhong, GAO Chang-ming,LI Su-ping,ZHOU Jian-nong,SU Ping,LIU Yan-ting,ZHOU Xue-fu,WANF Ru-hong,DING Bao-guo   

  1. Department of Epidemiology, Institute of Cancer Research, Nanjing 210009,Jiangsu,China
  • Received:2004-07-28 Revised:2004-10-19 Online:2005-09-30 Published:2005-09-30
  • Contact: CAO Hai-xia

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Abstract: BACKGROUND ＆ AIM: To analyze the genotype frequency of alcohol dehydrogenase-2 (ADH2), and evaluate the relationship between ADH2 polymorphism and drinking behavior in Chinese. MATERIAL AND METHODS: Epidemiological data were collected from 207 healthy persons in Taixing city of Jiangsu province, China, and ADH2 genotypes were determined by polymerase chain reattion restriction-fragment length polymorphism,(PCR -RFLP) method. RESULTS: The frequencies of , and genotypes were 12.6％, 46.8％ and 40.6％ respectively. Significant differences were found in the frequency of ADH2 genotypes between drinkers and no-drinkers. Cumularivy amounts of alcohol consumption were found statistically different among drinkers with different ADH2 genotypes. CONCLUSION: Drinking behavior was influenced by the individual genotypes of ADH2.

Key words: alcohol dehydrogenase 2, drinking, alcohol