Abstract: Purpose : To study the migration of the residual compounds f rom VDC/ VC copolymer products into food - simulating solvent s (e. g. distilled water , 4 % acetic acid , and hexane) , and the mutagenicity of migration. Methods : We used two pret reated methods in this experimental research , and studied the difference between f rozen - drying and heating method. The mutagenicity of migration was measured by Ames test . Results : The result s f rom the studies indicated that the migration f rom f rozen - drying increased by 6～27 times as compared with it f rom heating. The test for mutagenicity of migration was always negative for the storage periods of three months by Ames test with two S almonella st rains ( TA98 , TA100) , with and without S9. Conclusion : The studies suggested that the mutagenicity of the VDC/ VC copolymer was not observed in this experimental condition.

Key words: VDC/ VC copolymer, migration, mutagenicity