NF-κB介导线粒体依赖的神经细胞凋亡途径

doi:10.3969/j.issn.1004-616x.2014.01.018

摘要/Abstract

摘要：

中枢神经系统损伤往往伴随着大量神经细胞凋亡，凋亡过程中许多重要环节的发生均与细胞内源性凋亡通路线粒体途径密切相关，由各种上游信号通路介导的线粒体凋亡机制是多年研究的热点。诸多信号通路中，其中具有多向转录调节作用的蛋白质核转录因子(NF-κB)的活化更引起人们的关注，其在神经细胞的增殖、转化、凋亡和死亡等多种生理和病理过程中起重要作用，但具体促凋亡的机制尚不明确。因此深入研究NF-κB通路与线粒体依赖的神经细胞凋亡途径之间的关系，将有助于开辟防治中枢神经系统损伤的新途径。本文就NF-κB介导线粒体依赖的神经细胞凋亡途径作一综述。

关键词: 信号通路, 线粒体, 细胞凋亡, 中枢神经系统

吴卓超，宋英，宋必卫. NF-κB介导线粒体依赖的神经细胞凋亡途径[J]. 癌变·畸变·突变, doi: 10.3969/j.issn.1004-616x.2014.01.018.

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