RAC1对恶性肿瘤的调控作用及其分子机制研究进展

doi:10.3969/j.issn.1004-616x.2021.05.016

癌变·畸变·突变 ›› 2021, Vol. 33 ›› Issue (5): 401-404.doi: 10.3969/j.issn.1004-616x.2021.05.016

• 综述 • 上一篇

RAC1对恶性肿瘤的调控作用及其分子机制研究进展

王琛瑶^1,2, 梁百慧³, 吴锦源⁴, 唐梓涵⁵, 许小文⁵, 尹梓健⁴, 丁雅琼³, 方雄钊¹, 李栢芝¹, 文姝佚³, 程转⁴, 詹涵⁵, 张粤烽⁵, 王泫哲⁴, 何仕龙³, 张可洵¹, 刘雅骐¹, 周飞⁵, 熊兴东⁴, 白春英³, 许丽艳¹, 李恩民^1,2

1. 汕头大学医学院生物化学与分子生物学教研室, 广东汕头 515041;
2. 汕头大学医学院基础医学研究所, 广东汕头 515041;
3. 赤峰学院基础医学院, 内蒙古赤峰 024076;
4. 广东医科大学基础医学院, 广东东莞 523808;
5. 韩山师范学院生命科学与食品工程学院, 广东潮州 521041

收稿日期:2021-05-06 修回日期:2021-08-13 出版日期:2021-09-30 发布日期:2021-10-09
通讯作者: 李恩民,E-mail:nmli@stu.edu.cn E-mail:nmli@stu.edu.cn
作者简介:王琛瑶,E-mail:18cywang3@stu.edu.cn。
基金资助:
广东省大学生创新训练计划项目（202010560034）；广东省科技创新战略专项（620-14102109）

Received:2021-05-06 Revised:2021-08-13 Online:2021-09-30 Published:2021-10-09

摘要/Abstract

摘要： RAS相关C3肉毒杆菌毒素底物1（RAC1）是小G蛋白超家族中Rho亚家族的核心成员，在与GTP结合（激活态）和与GDP结合（失活态）之间转换，发挥细胞信号通路分子开关的作用，主要涉及细胞迁移侵袭和细胞黏附等细胞生物学过程。研究表明，RAC1在许多恶性肿瘤中异常过表达，与肿瘤的发生发展密切相关；然而，其中的分子机制尚不甚明晰。关于RAC1与肿瘤，长期以来，一直是肿瘤研究领域的热点。近年，围绕着异常表达的RAC1如何促进肿瘤细胞恶性增殖与迁移侵袭，如何调节肿瘤细胞糖酵解/能量代谢等重要科学问题，取得了一些令人瞩目的新进展。基于此，本文在简要介绍RAC1基因和蛋白结构特点及其生物学功能的基础之上，重点就RAC1如何促进肿瘤细胞恶性增殖与迁移侵袭，如何调节肿瘤细胞糖酵解/能量代谢等重要问题予以综述。

关键词: RAC1, 恶性肿瘤, 增殖, 迁移, 细胞信号通路

中图分类号:

R73-3

王琛瑶, 梁百慧, 吴锦源, 唐梓涵, 许小文, 尹梓健, 丁雅琼, 方雄钊, 李栢芝, 文姝佚, 程转, 詹涵, 张粤烽, 王泫哲, 何仕龙, 张可洵, 刘雅骐, 周飞, 熊兴东, 白春英, 许丽艳, 李恩民. RAC1对恶性肿瘤的调控作用及其分子机制研究进展[J]. 癌变·畸变·突变, 2021, 33(5): 401-404.

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RAC1对恶性肿瘤的调控作用及其分子机制研究进展

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