儿童原发性激素敏感型肾病综合征与ACE基因多态性关系的meta分析

doi:10.3969/j.issn.1004-616x.2018.06.006

癌变·畸变·突变 ›› 2018, Vol. 30 ›› Issue (6): 447-451.doi: 10.3969/j.issn.1004-616x.2018.06.006

儿童原发性激素敏感型肾病综合征与ACE基因多态性关系的meta分析

徐石张¹, 谢敏娟²

1. 宜春市人民医院肾内科, 江西宜春 336000;
2. 宜春学院病理教研室, 江西宜春 336000

收稿日期:2017-08-14 修回日期:2018-05-24 出版日期:2018-11-30 发布日期:2018-11-30
通讯作者: 谢敏娟,E-mail:1059139963@qq.com E-mail:1059139963@qq.com
作者简介:徐石张,E-mail:380746203@qq.com。

Relation between ACE gene polymorphism and pediatric idiopathic steroid-sensitive nephrotic syndrome: a meta-analysis

XU Shizhang¹, XIE Minjuan²

1. Department of Nephrology, The People's Hospital of Yichun City, Yichun 336000;
2. Department of Pathology, Yichun University, Yichun 336000, Jiangxi, China

Received:2017-08-14 Revised:2018-05-24 Online:2018-11-30 Published:2018-11-30

摘要/Abstract

摘要： 目的：系统性评价儿童原发性激素敏感型肾病综合征（SSNS）与血管紧张素转换酶（ACE）基因多态性的关系。方法：检索PubMed、Cochrane Library、EMBASE、Science Citation Index、Wiley Online Library和Google Scholar等在线数据库，依照纳入与排除标准，获得符合要求的文献后，利用Review Manager 5.1软件，分析ACE基因多态性与儿童激素敏感型肾病综合征（SSNS）的关系，以及不同亚组[不同种族、是否符合Hardy-Weinberg平衡（HWE）]中基因型DD、Ⅱ与儿童SSNS的关系。结果：此次研究纳入10篇文献，共包含1 617例研究对象，其中包含SSNS患儿524例，正常对照1 093例。在SSNS患儿中，ACE基因的等位基因D、基因型DD与基因型Ⅱ频率与对照组的差异均无统计学意义（P均 > 0.05）。在亚洲组和HWE组两个亚组中，基因型Ⅱ频率SSNS组均明显低于正常对照组（P均 < 0.01），且未发现异质性。结论：在儿童原发性肾病综合征中，ACE基因的缺失及基因型与激素疗效的相关性不确定。

关键词: 血管紧张素转换酶, 基因多态性, 儿童, 激素敏感型, 肾病综合征, meta分析

Abstract: OBJECTIVE: To assess the relation of idiopathic steroid-sensitive nephrotic syndrome (SSNS) and ACE gene polymorphism in children. METHODS: To search from the database of PubMed,Cochrane Library,EMBASE,Science Citation Index,Wiley Online Library and Google Scholar,and obtained literatures according to the selection criteria,extracted relevant data and performed statistical analysis by Review Manager 5.1. RESULTS: A total of 10 publications including 1 617 subjects were screened out (524 SSNS children and 1 093 normal people). In the SSNS children,the frequency of D allele,DD genotype and Ⅱ genotype were higher than that in controls but the difference was not statistically significant. CONCLUSION: Our data did not show a polymorphism in the ACE gene was related to idiopathic SSNS.

Key words: angiotensin converting enzyme, gene polymorphism, pediatric, steroid-sensitive, nephritic syndrome, meta-analysis

中图分类号:

R363.1

徐石张, 谢敏娟. 儿童原发性激素敏感型肾病综合征与ACE基因多态性关系的meta分析[J]. 癌变·畸变·突变, 2018, 30(6): 447-451.

XU Shizhang, XIE Minjuan. Relation between ACE gene polymorphism and pediatric idiopathic steroid-sensitive nephrotic syndrome: a meta-analysis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(6): 447-451.

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儿童原发性激素敏感型肾病综合征与ACE基因多态性关系的meta分析

Relation between ACE gene polymorphism and pediatric idiopathic steroid-sensitive nephrotic syndrome: a meta-analysis

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