癌变·畸变·突变 ›› 1998, Vol. 10 ›› Issue (1): 42-045.doi: 10.3969/j.issn.1004-616x.1998.01.013

• 论著 • 上一篇    下一篇

格兰西隆的致突变性研究

贺清玉　印木泉　陆　敦　陈耀富　毕　洁　刘　建   

  1. 第二军医大学基础部卫生毒理学教研室　上海200433
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-01-30 发布日期:1998-01-30

STUDIED ON MUTAGENICITY OF GRANISETRON

He Qingyu , Yin Muqun , Lu Dun , Chen Yaofu Bi J ie Liu J ian   

  1. Department of Hygienic Toxicology , Second Military medical University , S hanghai 　200433
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-01-30 Published:1998-01-30

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摘要： 应用Ames 试验,体外染色体畸变试验和微核试验对格兰西隆进行了致突变性研究。研究结果,格兰西隆的各剂量组对TA98 ,TA97 ,TA100 ,TA102 在加和不加S9mix 条件下均无致突变性,染色体畸变试验中,在加S9mix 条件下,15μg/ ml 和30μg/ ml 剂量对CHL 细胞诱发的畸变率分别为6 %和7 % ,为阳性。以418mg/ kg 剂量以上对小鼠骨髓多染红细胞有诱发微核作用。实验结果提示,格兰西隆具有潜在致突变性。

关键词: 格兰西隆, Ames 试验, 微核试验, 染色体畸变试验, 致突变性

Abstract: The Mutageicity of Graniset ron was studied by Ames test , chromosome aberration assay of mammlian cell (CHL) in vit ro and mouse marrow micronucleus assay. The results showed that Graniset ron had no mutagenicity on salmonella typhimurium st rain TA97 , TA98 , TA100 and TA102 with or mithout S9 mix. Chromosome aberration rates induced by 15μg/ ml and 30μg/ ml doses with S9 mix were 6 % and 7 % respectively , Possible postive. The freqaency of male mice micronuleus rate induced by 4. 8mg/ kg dose were signifioant disfereonces as Compared with negative cont rocl ( P < 0. 01) , The result s showed that Graniset ron more than 4. 8mg/ kg Graniset ron Could also induce mouse marrow micronucleus rates increase , So. Graniset ron is mutagenic.

Key words: Graniset ron, Ames test, Chromosome aberration test, Micronucleus test, mutagenicity

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